Gene: SERPINB6
Official Full Name: serpin family B member 6provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36097 | SERPINB6 Knockout cell line (HeLa) | Human | SERPINB6 | 1:3~1:6 | Negative | Online Inquiry |
KO36098 | SERPINB6 Knockout cell line (HCT 116) | Human | SERPINB6 | 1:2~1:4 | Negative | Online Inquiry |
KO36099 | SERPINB6 Knockout cell line (HEK293) | Human | SERPINB6 | 1:3~1:6 | Negative | Online Inquiry |
KO36100 | SERPINB6 Knockout cell line (A549) | Human | SERPINB6 | 1:3~1:4 | Negative | Online Inquiry |
SERPINB6 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the SERPINB6 gene, which encodes for a member of the serpin superfamily of proteins that act primarily as serine protease inhibitors. These cell lines are essential for researching the physiological roles of SERPINB6, including its involvement in immune response and apoptosis regulation. The knockout mechanism facilitates the complete disruption of the endogenous SERPINB6 gene, allowing for a clearer assessment of its functional contributions in various biological processes.
The key function of these cell lines lies in their ability to model the effects of SERPINB6 deficiency in vitro, enabling researchers to monitor changes in cell behavior, signal transduction pathways, and protease activities. This controlled environment allows for a more profound understanding of how SERPINB6 modulates cellular responses to stress and inflammation. Furthermore, the use of these knockout models can improve the investigation into diseases where SERPINB6 is implicated, such as autoimmune conditions and certain cancers, thereby bridging a significant gap in current biological research.
Leveraging SERPINB6 Gene Knockout Cell Lines provides distinct advantages compared to other models, such as overexpression systems or wild-type cells. Researchers benefit from the precise elimination of SERPINB6-associated activities, offering a more direct correlation between gene function and cellular phenotypes. Additionally, these cell lines can be utilized in drug discovery and therapeutic development processes, presenting opportunities to explore novel treatment avenues targeting SERPINB6-related pathways.
For researchers and clinicians, the value of these knockout cell lines is paramount. They not only facilitate groundbreaking discoveries in fundamental and applied sciences but also enhance the potential for clinical translations in the treatment of disorders mediated by serine proteases. Our company specializes in providing high-quality biological products that empower scientific innovation and discovery. By investing in SERPINB6 Gene Knockout Cell Lines, you are equipping yourself with a tool vital for advancing your research and clinical applications in the ever-evolving field of cellular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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