Gene: SERPINA3
Official Full Name: serpin family A member 3provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jun 2020]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03921 | SERPINA3 Knockout cell line (A549) | Human | SERPINA3 | 1:3~1:4 | Negative | Online Inquiry |
SERPINA3 Gene Knockout Cell Lines are genetically engineered cell lines that have had the SERPINA3 gene selectively disrupted or "knocked out" using advanced gene-editing techniques such as CRISPR-Cas9. This product is designed to facilitate the study of SERPINA3's biological functions and its role in various disease processes, particularly in cancer and inflammation. By removing the expression of this specific gene, researchers can investigate the downstream effects on cellular pathways, gene interactions, and protein expressions, providing vital insights into the physiological and pathological roles of SERPINA3.
The key function of SERPINA3 knockout cell lines lies in their ability to mimic disease states and contribute to a deeper understanding of underlying mechanisms in diseases where SERPINA3 modulation is implicated. The deletion of this gene can affect cellular proliferation, migration, and response to external stimuli, making it an invaluable tool for researchers interested in the dual role of SERPINA3 as both a serpin and a modulator of immune responses. Moreover, these cell lines serve as a platform for drug discovery and therapeutic intervention studies aimed at targeting SERPINA3 pathways.
Scientifically, SERPINA3 knockout cell lines hold significant importance, particularly in research and clinical settings focused on therapeutic development and biomarker discovery. Their applications range from basic research exploring apoptosis and tumorigenesis to translational research, where they can assist in preclinical trials and personalized medicine approaches.
Compared to conventional cell lines that express SERPINA3, our knockout cell lines offer distinct advantages. Researchers benefit from clean background noise, enabling a clearer analysis of experimental results. Additionally, our cell lines come with comprehensive validation protocols, ensuring reliable replication of findings across different studies.
For researchers, clinicians, and pharmaceutical companies, SERPINA3 Gene Knockout Cell Lines represent a powerful and flexible tool that can accelerate discovery and development processes. Our commitment to high-quality genetic engineering and thorough understanding of cell biology sets us apart. With our extensive experience in creating tailored biological solutions, we are dedicated to advancing research with products that provide clarity and efficacy.
Please note that all services are for research use only. Not intended for any clinical use.
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