Gene: SEPTIN7
Official Full Name: septin 7provided by HGNC
Gene Summary: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. [provided by RefSeq, Jul 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38622 | SEPTIN7 Knockout cell line (HeLa) | Human | SEPTIN7 | 1:3~1:6 | Negative | Online Inquiry |
KO38623 | SEPTIN7 Knockout cell line (HCT 116) | Human | SEPTIN7 | 1:2~1:4 | Negative | Online Inquiry |
KO38624 | SEPTIN7 Knockout cell line (HEK293) | Human | SEPTIN7 | 1:3~1:6 | Negative | Online Inquiry |
KO38625 | SEPTIN7 Knockout cell line (A549) | Human | SEPTIN7 | 1:3~1:4 | Negative | Online Inquiry |
SEPTIN7 Gene Knockout Cell Lines are a sophisticated biological tool designed for advanced genetic research, focusing on the functional analysis of the SEPTIN7 gene, a critical component associated with cytoskeletal dynamics, cell division, and membrane trafficking. These cell lines are specifically engineered to lack the expression of the SEPTIN7 gene, allowing for the precise study of its role in various cellular processes.
The primary function of SEPTIN7 gene knockout cell lines is to facilitate the exploration of the biological pathways influenced by SEPTIN7, including its involvement in neurodevelopment, tumorigenesis, and infection mechanisms. By utilizing CRISPR-Cas9 gene-editing technology, these cell lines provide a reliable model for investigating the phenotypic consequences of SEPTIN7 absence. Researchers can discern alterations in cellular morphology, proliferation rates, and apoptosis, thus obtaining valuable insights into the gene's functional significance.
The scientific importance of SEPTIN7 gene knockout cell lines is underscored by their applications in both basic and applied research, particularly in cancer biology, neurobiology, and infectious diseases. They serve as an essential resource for drug discovery and validation studies, where understanding gene functionalities can lead to the development of targeted therapies.
Compared to other gene knockout lines, SEPTIN7 gene knockout cell lines offer specific advantages including high efficiency of gene targeting, ease of handling, and the ability to be propagated through standard culture techniques. These features, combined with high reproducibility, make them a superior choice over transient knockdown methods, which often yield inconsistent results.
For researchers, clinicians, and pharmaceutical developers, SEPTIN7 gene knockout cell lines represent a valuable asset for elucidating the role of septins in health and disease. The precision of this product not only enhances experimental throughput but also supports the discovery of novel therapeutic strategies.
Our company is committed to advancing cellular and molecular research, leveraging years of expertise in genetic engineering and cell line development to provide innovative, high-quality biological products, including the outstanding SEPTIN7 gene knockout cell lines.
Please note that all services are for research use only. Not intended for any clinical use.
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