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SEMA4D Knockout Cell Lines

Gene: SEMA4D

Official Full Name: semaphorin 4Dprovided by HGNC

Gene Summary: Enables identical protein binding activity; semaphorin receptor binding activity; and transmembrane signaling receptor activity. Involved in several processes, including ossification involved in bone maturation; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of neuron projection development. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09837 SEMA4D Knockout cell line (HeLa) Human SEMA4D 1:3~1:6 Negative Online Inquiry
KO09838 SEMA4D Knockout cell line (HCT 116) Human SEMA4D 1:2~1:4 Negative Online Inquiry
KO09839 SEMA4D Knockout cell line (HEK293) Human SEMA4D 1:3~1:6 Negative Online Inquiry
KO09840 SEMA4D Knockout cell line (A549) Human SEMA4D 1:3~1:4 Negative Online Inquiry

Background

SEMA4D Gene Knockout Cell Lines are genetically engineered cellular models designed to lack the SEMA4D gene, which encodes a crucial member of the semaphorin family involved in axon guidance, immune response, and various oncogenic processes. These knockout cell lines facilitate the elucidation of SEMA4D's diverse roles in cell signaling and interaction, enabling a deeper understanding of its implications in both normal physiological and pathological contexts.

The primary function of these cell lines is to serve as an experimental platform for investigating the signaling pathways modulated by SEMA4D. By removing the gene, researchers can assess changes in cellular behavior, migration, proliferation, and differentiation. This knockout model proves invaluable for dissecting the mechanism of SEMA4D in immune cell modulation and tumorigenesis, as it allows for the observation of how its absence impacts adjacent molecular networks and cellular functions.

In the realm of scientific research and clinical application, SEMA4D Gene Knockout Cell Lines hold significant importance. They can be employed in the study of autoimmune diseases and cancers, where SEMA4D is implicated in immune evasion and tumor progression. These cell lines can also leverage high-throughput screening assays for drug discovery efforts aimed at targeting SEMA4D-related pathways.

One of the key advantages of using SEMA4D Gene Knockout Cell Lines is the specificity and reliability they offer in experimental designs, providing clear comparison data against wild-type controls. This specificity enhances the reproducibility and validation of results, distinguishing these models from traditional cell lines that may present confounding variables.

For researchers and clinicians, the value lies in the ability to systematically unravel the complex roles of SEMA4D, potentially leading to novel therapeutic strategies in immune modulation and cancer treatment. Our company leverages extensive expertise in genetic engineering and cell biology to provide high-quality, reliable cell lines that meet the rigorous demands of today's research landscape. We are committed to supporting scientific innovation with our premium biological products designed to advance understanding and treatment options in health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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