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SEMA3F Knockout Cell Lines

Gene: SEMA3F

Official Full Name: semaphorin 3Fprovided by HGNC

Gene Summary: This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-terminal basic domain. This gene is expressed by the endothelial cells where it was found to act in an autocrine fashion to induce apoptosis, inhibit cell proliferation and survival, and function as an anti-tumorigenic agent. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35480 SEMA3F Knockout cell line (HeLa) Human SEMA3F 1:3~1:6 Negative Online Inquiry
KO35481 SEMA3F Knockout cell line (HCT 116) Human SEMA3F 1:2~1:4 Negative Online Inquiry
KO35482 SEMA3F Knockout cell line (HEK293) Human SEMA3F 1:3~1:6 Negative Online Inquiry
KO35483 SEMA3F Knockout cell line (A549) Human SEMA3F 1:3~1:4 Negative Online Inquiry

Background

SEMA3F Gene Knockout Cell Lines are genetically modified cell lines engineered to lack the expression of the SEMA3F gene, which encodes a protein that plays a crucial role in neuronal development and guidance. These knockout cell lines serve as invaluable tools for elucidating the biological functions of SEMA3F, particularly in relation to axon guidance, neural patterning, and interactions within the tumor microenvironment.

The key function of SEMA3F revolves around its capacity to regulate cellular signaling pathways pertinent to cell migration and growth. By producing knockout cell lines, researchers gain critical insights into the mechanisms by which SEMA3F influences neurodevelopmental processes and its implications in various pathologies, including cancers and neurological disorders. Functionally, the absence of SEMA3F in these cell lines allows for the exploration of its role in inhibiting cell proliferation and migration, offering avenues for therapeutic interventions.

The scientific importance of SEMA3F knockout cell lines is evident in their diverse applications for both basic research and clinical settings. They provide a platform for high-throughput screening of compounds that modulate the effects of SEMA3F and can facilitate studies investigating therapeutic targets in neurodegenerative diseases.

Compared to alternative models, such as wild-type cells or other gene knockout systems, SEMA3F knockout cell lines offer a specific focus on SEMA3F-related pathways and are meticulously validated for robustness in experimentation. This precision allows researchers to obtain clearer, more reproducible results.

Investing in SEMA3F Gene Knockout Cell Lines equips researchers and clinicians with a refined tool to explore intricate biological mechanisms and develop novel therapeutic strategies. Our company, backed by leading expertise in genetic engineering and cell line development, is committed to providing high-quality biological products designed to advance research and improve patient outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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