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SELENOI Knockout Cell Lines

Gene: SELENOI

Official Full Name: selenoprotein Iprovided by HGNC

Gene Summary: The multi-pass transmembrane protein encoded by this gene belongs to the CDP-alcohol phosphatidyltransferase class-I family. It catalyzes the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to produce phosphatidylethanolamine, which is involved in the formation and maintenance of vesicular membranes, regulation of lipid metabolism, and protein folding. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24185 SELENOI Knockout cell line (HeLa) Human SELENOI 1:3~1:6 Negative Online Inquiry
KO24186 SELENOI Knockout cell line (HCT 116) Human SELENOI 1:2~1:4 Negative Online Inquiry
KO24187 SELENOI Knockout cell line (HEK293) Human SELENOI 1:3~1:6 Negative Online Inquiry
KO24188 SELENOI Knockout cell line (A549) Human SELENOI 1:3~1:4 Negative Online Inquiry

Background

SELENOI Gene Knockout Cell Lines are a revolutionary biological tool designed to facilitate the study of the SELENOI gene, known for its critical role in selenium metabolism and overall cellular function. By utilizing CRISPR-Cas9 technology, these cell lines provide researchers with a unique platform to knock out the SELENOI gene effectively, enabling the analysis of gene function and its implications in various physiological and pathological processes.

The key mechanism of the SELENOI Gene Knockout Cell Lines involves the precise editing of the target gene, allowing scientists to investigate the effects of eliminating SELENOI expression on cellular pathways, antioxidant defenses, and response to oxidative stress. The ability to create a complete knockout of SELENOI opens avenues for understanding its role in diseases linked to selenium deficiency, such as certain cancers and neurological disorders.

In research and clinical settings, these cell lines are invaluable for uncovering the intricate biochemical pathways involved in selenium-dependent processes. They serve as a critical tool for drug discovery and development, offering insights into potential therapeutic targets for enhancing antioxidant defense mechanisms. Furthermore, the SELENOI knockout model is instrumental in the study of basic cellular biology, providing a clearer understanding of gene interactions in metabolic pathways.

Unlike traditional knockout models, SELENOI Gene Knockout Cell Lines provide a more specific and controlled genetic alteration. Their ease of use, combined with reproducibility, ensures consistent outcomes, making them preferable to other methods that may lack precision or require extensive validation.

Researchers, clinicians, and biotechnologists will find immense value in these cell lines, not only for their academic pursuits but also for accelerating translational research aimed at developing selenium-based therapeutics. Our company is dedicated to advancing biological research through innovative products like the SELENOI Gene Knockout Cell Lines, backed by our expertise in genetic engineering and a commitment to supporting the scientific community in groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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