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SEC23B Knockout Cell Lines

Gene: SEC23B

Official Full Name: SEC23 homolog B, COPII coat complex componentprovided by HGNC

Gene Summary: The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09800 SEC23B Knockout cell line (HeLa) Human SEC23B 1:3~1:6 Negative Online Inquiry
KO09801 SEC23B Knockout cell line (HCT 116) Human SEC23B 1:2~1:4 Negative Online Inquiry
KO09802 SEC23B Knockout cell line (HEK293) Human SEC23B 1:3~1:6 Negative Online Inquiry
KO09803 SEC23B Knockout cell line (A549) Human SEC23B 1:3~1:4 Negative Online Inquiry

Background

SEC23B Gene Knockout Cell Lines are specialized cell lines engineered to have a targeted disruption of the SEC23B gene, which encodes a vital component of the coat protein complex II (COPII) machinery responsible for the transport of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus. By knocking out the SEC23B gene, these cell lines provide a powerful tool for researchers to study the cellular and molecular mechanisms of protein trafficking, particularly in relation to various diseases such as congenital disorders and metabolic syndromes.

The primary function of SEC23B Gene Knockout Cell Lines is to elucidate the roles of defective protein transport mechanisms. The absence of SEC23B leads to disrupted COPII vesicle formation, thereby affecting the secretion of proteins and contributing to the understanding of pathophysiological processes linked to protein misfolding and cellular stress responses. These cell lines can be employed in diverse applications including the assessment of drug efficacy, investigation of genetic disorders, and the exploration of therapeutic targets.

In the context of scientific importance, SEC23B Gene Knockout Cell Lines are invaluable for academic and industrial research settings. They enable researchers to model human diseases more accurately and examine the functional consequences of SEC23B loss. Compared to traditional cell lines, these knockouts allow for more precise studies related to gene function and protein interactions, providing insights that may lead to novel therapeutic interventions.

One of the specific advantages of SEC23B Gene Knockout Cell Lines is their ability to mimic conditions observed in patients with SEC23B-related disorders. This characteristic sets them apart from alternative models, including wild type or non-specific knockdown systems. They also offer reproducibility in experiments, ensuring that results are consistent and translatable to clinical scenarios.

Ultimately, SEC23B Gene Knockout Cell Lines are a valuable asset for researchers and clinicians aiming to deepen their understanding of protein transport mechanisms and their implications in health and disease. Our company prides itself on delivering high-quality biological products underpinned by rigorous scientific research and expertise. Our commitment to advancing the field ensures that researchers and clinicians receive innovative tools for their investigations and therapeutic development.

Please note that all services are for research use only. Not intended for any clinical use.

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