Home / SCP2 Knockout Cell Lines

SCP2 Knockout Cell Lines

Gene: SCP2

Official Full Name: sterol carrier protein 2provided by HGNC

Gene Summary: This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[provided by RefSeq, Aug 2010]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35492 SCP2 Knockout cell line (HeLa) Human SCP2 1:3~1:6 Negative Online Inquiry
KO35493 SCP2 Knockout cell line (HCT 116) Human SCP2 1:2~1:4 Negative Online Inquiry
KO35494 SCP2 Knockout cell line (HEK293) Human SCP2 1:3~1:6 Negative Online Inquiry
KO35495 SCP2 Knockout cell line (A549) Human SCP2 1:3~1:4 Negative Online Inquiry

Background

SCP2 Gene Knockout Cell Lines represent a sophisticated cellular model developed for the detailed study of the SCP2 gene's role in lipid metabolism, cellular signaling pathways, and overall cellular function. By utilizing CRISPR-Cas9 genome editing technology, these cell lines have undergone precise disruption of the SCP2 gene, eradicating its expression and allowing researchers to probe the gene's physiological and pathological implications.

The primary function of SCP2 gene knockout cell lines is to facilitate the investigation of SCP2's involvement in lipid transport and metabolism. SCP2, known as Sterol Carrier Protein 2, plays a critical role in the intracellular trafficking of lipids, which are essential for cell membrane formation, energy storage, and signaling pathways. The knockout system allows researchers to observe alterations in cellular pathways, lipid biosynthesis, and gene expression profiles when SCP2 function is lost, thereby aiding in the elucidation of its biological significance.

The scientific implications of SCP2 Gene Knockout Cell Lines are profound. They serve as powerful tools in both basic and translational research settings. In basic science, they provide insights into the mechanisms of lipid metabolism disorders, which are linked to a variety of diseases, including cardiovascular diseases and metabolic syndromes. In translational research, these models are instrumental for the development of new therapeutic strategies targeting lipid metabolism.

What sets SCP2 Gene Knockout Cell Lines apart from alternative models is the precision and specificity achieved through advanced genome editing techniques. The creation of these cell lines ensures consistent and reproducible genetic modifications, which is crucial for obtaining reliable data. Additionally, they come with thorough validation and characterization reports, providing confidence in the results obtained from experiments.

For researchers and clinicians focused on elucidating the complexities of lipid metabolism and its implications for human health, SCP2 Gene Knockout Cell Lines represent a valuable asset. The ability to link specific genetic disruptions to functional outcomes broadens the understanding of metabolic pathways and opens new avenues for novel therapeutic developments.

Our company prides itself on a commitment to excellence in developing innovative biological products and providing cutting-edge tools for researchers. With a dedicated team of experts in cell biology and genetic engineering, we ensure that our products not only meet the highest scientific standards but also support the ongoing advancement of research in lipid biology and metabolic diseases.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.