Gene: SCD5
Official Full Name: stearoyl-CoA desaturase 5provided by HGNC
Gene Summary: Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07440 | SCD5 Knockout cell line (HeLa) | Human | SCD5 | 1:3~1:6 | Negative | Online Inquiry |
KO07441 | SCD5 Knockout cell line (HCT 116) | Human | SCD5 | 1:2~1:4 | Negative | Online Inquiry |
KO07442 | SCD5 Knockout cell line (HEK293) | Human | SCD5 | 1:3~1:6 | Negative | Online Inquiry |
KO07443 | SCD5 Knockout cell line (A549) | Human | SCD5 | 1:3~1:4 | Negative | Online Inquiry |
SCD5 Gene Knockout Cell Lines are specialized models designed to study the function and impact of the SCD5 gene, which encodes for stearoyl-CoA desaturase 5, an enzyme playing a crucial role in lipid metabolism. These knockout cell lines are created using advanced CRISPR-Cas9 gene-editing technology to disrupt the SCD5 gene, resulting in the loss of its functional expression. This genetic modification allows researchers to investigate the physiological consequences of SCD5 deficiency, particularly its effects on fatty acid composition, insulin sensitivity, and overall cellular metabolism.
The primary function of SCD5 is to facilitate the conversion of saturated fatty acids into monounsaturated fatty acids, which are vital for maintaining cellular lipid homeostasis and membrane fluidity. By utilizing our SCD5 Gene Knockout Cell Lines, scientists can elucidate mechanisms involving lipid metabolism and assess the implications of altered lipid profiles on various biological processes. Such studies have significant implications in understanding metabolic disorders, obesity, and associated diseases such as diabetes and cardiovascular conditions.
Our SCD5 Gene Knockout Cell Lines present a significant advantage over traditional models due to the precise targeting of the SCD5 gene, ensuring reproducibility and specificity in experimental outcomes. Furthermore, these cell lines are readily adaptable, allowing for robust in vitro experimentation that can seamlessly integrate into existing research protocols.
Researchers and clinicians can leverage these knockout lines to gain insights that could inform therapeutic strategies or lead to the discovery of novel biomarkers for metabolic diseases. By choosing our SCD5 Gene Knockout Cell Lines, users are equipped with a powerful tool that enhances the depth and quality of their research.
At our company, we are dedicated to advancing the field of biological research through innovative products and solutions. Our expertise in genetic engineering, combined with a commitment to quality, ensures that our offerings meet the highest standards for scientific inquiry and application.
Please note that all services are for research use only. Not intended for any clinical use.
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