Gene: SCARF1
Official Full Name: scavenger receptor class F member 1provided by HGNC
Gene Summary: The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00075 | SCARF1 Knockout cell line (HEK293) | Human | SCARF1 | 1:3~1:6 | Negative | Online Inquiry |
KO00166 | SCARF1 Knockout cell line (293T) | Human | SCARF1 | 1:3~1:6 | Negative | Online Inquiry |
SCARF1 Gene Knockout Cell Lines are meticulously engineered cellular models designed to investigate the functional roles of the SCARF1 gene within various biological contexts. This gene is essential in modulating immune responses and facilitating cellular interaction with apoptotic cells. The SCARF1 Gene Knockout Cell Lines utilize CRISPR/Cas9 technology to create targeted deletions within the SCARF1 gene, allowing researchers to observe the subsequent phenotypic alterations and molecular pathways affected by the gene’s absence.
The primary mechanism through which these knockout cell lines operate is by disrupting the SCARF1 gene expression, thereby leading to loss of function. This enables scientists to study the implications of SCARF1 on processes such as phagocytosis, inflammation, and apoptosis in controlled experimental settings. As a valuable tool in both academic and clinical research, these cell lines can illuminate the gene's role in various disease states, particularly those involving immune dysregulation and cancer biology.
One significant advantage of SCARF1 Gene Knockout Cell Lines is their specificity and reliability in mimicking physiological conditions seen in disease models, compared to general inhibitors or antibody-based approaches. Researchers benefit from the precise genetic modifications that allow for the examination of SCARF1-related pathways without the ambiguity associated with off-target effects.
Moreover, the availability of these cell lines empowers researchers and clinicians to design targeted studies that explore therapeutic avenues aimed at modulating immune responses, potentially leading to innovations in disease treatment strategies.
Our company brings expertise in providing high-quality genomic editing tools and cell line models, ensuring that researchers have access to reliable and reproducible products necessary for advancing their scientific inquiries. With SCARF1 Gene Knockout Cell Lines, we aim to support groundbreaking research that contributes to the understanding and therapeutics of complex biological challenges.
Please note that all services are for research use only. Not intended for any clinical use.
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