Gene: SARDH
Official Full Name: sarcosine dehydrogenaseprovided by HGNC
Gene Summary: This gene encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04371 | SARDH Knockout cell line (HCT 116) | Human | SARDH | 1:2~1:4 | Negative | Online Inquiry |
SARDH Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the SARDH gene, which encodes the enzyme, sarcosine dehydrogenase. This specific knockout creates a versatile platform for studying the functional roles of this gene and its implications in various physiological and pathological processes, particularly in cancer metabolism and neural function. By utilizing CRISPR-Cas9 technology, we achieve a precise disruption of the SARDH gene, allowing researchers to investigate alterations in metabolic pathways and the subsequent effects on cellular behavior without the confounding effects of SARDH activity.
The significance of SARDH Gene Knockout Cell Lines extends beyond mere gene-level studies; they are pivotal in elucidating the gene’s contributions to sarcosine metabolism, a compound implicated in tumor progression and neurodegenerative diseases. This dual relevance enables applications across oncology research and neurobiology, providing insights that could lead to novel therapeutic strategies or biomarker identification.
One of the standout advantages of our SARDH Gene Knockout Cell Lines is their reproducibility and reliability. Unlike competing models, these cell lines are fully characterized and validated, reducing batch-to-batch variability and ensuring consistent results. Additionally, our proprietary cell culture conditions optimize growth and viability, setting a benchmark for performance in various experimental conditions.
For researchers and clinicians, the value of SARDH Gene Knockout Cell Lines lies in their potential to simplify complex experiments while providing robust data essential for advancing scientific knowledge. This product embodies our commitment to high-quality biological tools, designed with the insights and needs of modern research in mind. As a trusted leader in the field, our company continues to support the scientific community with meticulously developed products that drive discoveries forward.
Please note that all services are for research use only. Not intended for any clinical use.
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