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Ripk1 Knockout Cell Lines

Gene: RIPK1

Official Full Name: receptor interacting serine/threonine kinase 1provided by HGNC

Gene Summary: This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00205 Ripk1 gRNA1-gRNA2 KO plasmid Ripk1 $850

Background

RIPK1 Gene Knockout Cell Lines are a critical tool in molecular biology, specifically designed to facilitate the study of cell signaling pathways involved in apoptosis, necroptosis, and inflammatory responses. The RIPK1 gene encodes the receptor-interacting protein kinase 1, which plays a pivotal role in mediating cell fate decisions. By utilizing CRISPR-Cas9 technology, these knockout cell lines allow researchers to create precise genetic alterations, leading to the complete disruption of RIPK1 expression. This manipulation is essential for understanding how cells respond to various stressors and cytokines, providing insights into the mechanisms of disease states such as cancer, neurodegeneration, and infections.

The functionality of RIPK1 Gene Knockout Cell Lines lies in their ability to enable the study of the non-redundant roles of RIPK1 in cell death pathways, helping to delineate the contributions of this kinase in pathological contexts. By observing the phenotypic changes and signaling alterations in these knockout models, researchers can uncover vital information regarding cellular responses to stimuli, drug resistance, and the potential therapeutic targets associated with various diseases.

Scientifically, these knockout models are significant as they bridge the gap between basic research and clinical applications. They offer a robust platform for drug screening, understanding disease mechanisms, and validating the efficacy of novel therapeutic agents. Unlike traditional methods, our RIPK1 gene knockout cell lines eliminate confounding factors and provide clear, interpretable results, greatly enhancing data reliability.

The unique selling points of our product include a high degree of specificity in gene editing, consistent cell line performance, and a user-friendly protocol for researchers who may be less experienced with genetic manipulation techniques. Moreover, these cell lines can be easily integrated into existing workflows and are compatible with various assays, making them versatile tools for any research laboratory.

For researchers and clinicians keen on elucidating the molecular underpinnings of cell death and inflammation, RIPK1 Gene Knockout Cell Lines present an invaluable asset. By advancing our understanding of these processes, the implications for developing targeted therapies become increasingly apparent, enhancing both research efficacy and therapeutic outcomes.

Our company specializes in providing high-quality biological products tailored for cutting-edge research, backed by a dedicated team of experts committed to supporting scientific innovation. With an emphasis on reliability and performance, we ensure our customers receive state-of-the-art tools to advance their research goals.

Please note that all services are for research use only. Not intended for any clinical use.

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