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RUVBL1 Knockout Cell Lines

Gene: RUVBL1

Official Full Name: RuvB like AAA ATPase 1provided by HGNC

Gene Summary: This gene encodes a protein that has both DNA-dependent ATPase and DNA helicase activities and belongs to the ATPases associated with diverse cellular activities (AAA+) protein family. The encoded protein associates with several multisubunit transcriptional complexes and with protein complexes involved in both ATP-dependent remodeling and histone modification. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01376 RUVBL1 Knockout cell line (HeLa) Human RUVBL1 1:3~1:6 Negative Online Inquiry

Background

RUVBL1 Gene Knockout Cell Lines represent a robust tool for molecular biology research, specifically designed to facilitate the study of RUVBL1 gene functions and associated pathways. The RUVBL1 gene encodes a protein that plays a critical role in various cellular processes, including chromatin remodeling, transcriptional regulation, and DNA repair. By creating specific knockout cell lines, researchers can efficiently analyze the phenotypic consequences of RUVBL1 loss, providing valuable insights into its role in development and disease.

The key function of RUVBL1 Gene Knockout Cell Lines lies in their ability to allow scientists to investigate the downstream effects of incapacity in RUVBL1-mediated pathways. Mechanistically, RUVBL1 functions as a helicase and is integral to chromatin remodeling complexes, influencing the accessibility of DNA to transcriptional machinery. With the knockout of RUVBL1, researchers can observe alterations in gene expression patterns and cellular behaviors, thereby elucidating its contribution to critical biological processes such as tumorigenesis and other cellular dysfunctions.

The scientific importance of these cell lines is underscored by their wide applications in both basic research and clinical settings. They serve as ideal models for exploring potential therapeutic targets in cancer and understanding the molecular mechanisms underlying various pathologies. Furthermore, these cell lines can be employed to assess drug efficacy, validate pharmacological targets, and perform genetic screening.

Compared to alternative methods such as RNA interference (RNAi) or CRISPR/Cas9-based approaches, RUVBL1 Gene Knockout Cell Lines offer a more stable and permanent genetic modification, ensuring reproducibility and consistency in experimental outcomes. This stability enables long-term studies of genetic influences on cellular physiology without the transient effects seen with other techniques.

For researchers, clinicians, and drug developers, these knockout cell lines are invaluable resources that facilitate advanced studies into the functional genomics of RUVBL1. Utilizing our expertise in genetic engineering and cell line development, our company is dedicated to providing high-quality and reliable research tools that advance the understanding of molecular biology. Our commitment to scientific excellence ensures that you can trust in the integrity and utility of our RUVBL1 Gene Knockout Cell Lines in your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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