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RTN4IP1 Knockout Cell Lines

Gene: RTN4IP1

Official Full Name: reticulon 4 interacting protein 1provided by HGNC

Gene Summary: This gene encodes a mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. This interaction may be important for reticulon-induced inhibition of neurite growth. Mutations in this gene can cause optic atrophy 10, with or without ataxia, cognitive disability, and seizures. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24612 RTN4IP1 Knockout cell line (HeLa) Human RTN4IP1 1:3~1:6 Negative Online Inquiry
KO24613 RTN4IP1 Knockout cell line (HCT 116) Human RTN4IP1 1:2~1:4 Negative Online Inquiry
KO24614 RTN4IP1 Knockout cell line (HEK293) Human RTN4IP1 1:3~1:6 Negative Online Inquiry
KO24615 RTN4IP1 Knockout cell line (A549) Human RTN4IP1 1:3~1:4 Negative Online Inquiry

Background

RTN4IP1 Gene Knockout Cell Lines are a specialized biological tool that enables the precise study of the RTN4IP1 gene by disrupting its function within mammalian cells. These cell lines are engineered through CRISPR/Cas9 technology, which allows for targeted gene editing, effectively creating a genetic knockout that eliminates the expression of the RTN4IP1 protein. The resulting alterations in the cellular pathways facilitate investigations into the gene’s roles in important physiological processes, including neuronal development and responses to cellular stress.

The key function of RTN4IP1 involves interactions that modulate neuronal cell survival and plasticity. By utilizing these knockout cell lines, researchers can explore the mechanisms underlying neurodegenerative diseases, elucidating pathways that may be potential therapeutic targets. The ability to study these cellular responses in a controlled environment allows for more robust experimental designs and a clearer understanding of disease mechanisms.

Scientifically, these cell lines are invaluable in both research and clinical settings, providing a powerful model for investigating the impact of RTN4IP1 deficiency. They can be utilized in drug discovery processes, advancing the development of novel therapies that aim to mitigate the effects of neurodegeneration. Unlike conventional cell lines that may retain functional versions of the target gene, RTN4IP1 Gene Knockout Cell Lines offer a unique and highly specific platform for examining the gene’s role without confounding background influences.

The advantages of these knockout cell lines are manifold; they offer reproducibility in experimental results, facilitate the analysis of gene function based on clear phenotypic differences, and provide a more cost-effective solution compared to labor-intensive gene silencing techniques. This product is particularly valuable for researchers and clinicians interested in identifying new interventions for conditions linked to RTN4IP1, such as dementia and multiple sclerosis.

Our company specializes in providing high-quality biological products that cater to the evolving needs of the research community. We are dedicated to advancing scientific understanding through innovative solutions like the RTN4IP1 Gene Knockout Cell Lines, ensuring our customers have access to the best tools for their investigations.

Please note that all services are for research use only. Not intended for any clinical use.

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