Gene: RTKN
Official Full Name: rhotekinprovided by HGNC
Gene Summary: This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35565 | RTKN Knockout cell line (HeLa) | Human | RTKN | 1:3~1:6 | Negative | Online Inquiry |
KO35566 | RTKN Knockout cell line (HCT 116) | Human | RTKN | 1:2~1:4 | Negative | Online Inquiry |
KO35567 | RTKN Knockout cell line (HEK293) | Human | RTKN | 1:3~1:6 | Negative | Online Inquiry |
KO35568 | RTKN Knockout cell line (A549) | Human | RTKN | 1:3~1:4 | Negative | Online Inquiry |
RTKN Gene Knockout Cell Lines are specialized cellular models designed to facilitate in-depth research into the role of the RTKN gene in various biological processes. These genetically modified cell lines contain a disruption in the RTKN gene, allowing researchers to study the phenotypic effects of gene loss in a controlled environment. By utilizing CRISPR/Cas9 or similar gene-editing technologies, these knockout lines enable precise studies of RTKN's function, including its involvement in signal transduction, cytoskeletal dynamics, and tumorigenesis.
The primary function of RTKN Gene Knockout Cell Lines is to elucidate the pathways and mechanisms that remain uncharacterized due to the challenges associated with studying native gene expression. By silencing RTKN, researchers can investigate the resultant cellular adaptations, compensatory mechanisms, and potential therapeutic target pathways. These cell lines are invaluable for understanding the gene’s role in diseases, particularly cancer, where aberrant signaling often leads to tumor progression and metastasis.
In addition to advancing basic biological knowledge, RTKN Gene Knockout Cell Lines have practical applications in drug development and precision medicine. They provide a relevant platform for high-throughput screening of potential therapeutic agents targeting altered pathways, thus accelerating the identification of effective treatments for diseases associated with RTKN dysregulation.
Compared to traditional cell line models, RTKN Gene Knockout Cell Lines offer specificity and reproducibility that is often lacking in studies utilizing wild-type cell lines. Their validated genetic modification ensures consistent results, allowing for more accurate interpretation of experimental data. Furthermore, this product comes with the backing of comprehensive technical support and detailed protocols, which streamline the research process, making it a user-friendly choice for both novice and seasoned researchers.
For researchers and clinicians invested in understanding the complexities of cellular signaling and disease mechanisms, RTKN Gene Knockout Cell Lines represent a crucial innovation. They not only enhance research outcomes but also contribute to a significant advancement in translational science. Our company specializes in providing high-quality biological reagents and models designed to meet the rigorous demands of contemporary research, ensuring that our products fulfill the evolving needs of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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