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RSF1 Knockout Cell Lines

Gene: RSF1

Official Full Name: remodeling and spacing factor 1provided by HGNC

Gene Summary: This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02339 RSF1 Knockout cell line (HeLa) Human RSF1 1:3~1:6 Negative Online Inquiry
KO02340 RSF1 Knockout cell line (HCT 116) Human RSF1 1:2~1:4 Negative Online Inquiry
KO02341 RSF1 Knockout cell line (HEK293) Human RSF1 1:3~1:6 Negative Online Inquiry
KO02342 RSF1 Knockout cell line (A549) Human RSF1 1:3~1:4 Negative Online Inquiry

Background

RSF1 Gene Knockout Cell Lines are innovative biological tools designed to facilitate in-depth research into the functions and regulatory mechanisms of the RSF1 gene, widely recognized for its role in chromatin remodeling and cancer development. This product consists of genetically modified cell lines where the RSF1 gene has been disrupted via CRISPR-Cas9 technology, leading to the absence of functional RSF1 protein expression. As a result, researchers can evaluate the physiological and pathological consequences of RSF1 loss, enabling a better understanding of its contributions to tumorigenesis and cellular differentiation.

The key functions of RSF1 knockout cell lines hinge on their ability to offer model systems that closely mimic the conditions of RSF1 deficiency in vivo. By utilizing these cell lines, scientists can assess alterations in gene expression, chromatin structure, and DNA damage response, allowing for comprehensive studies on mechanisms behind cancer progression and potential therapeutic targets.

Scientifically, these cell lines hold immense importance in both basic research and translational applications. They serve as essential platforms for drug discovery, helping researchers identify compounds that can modulate RSF1-related pathways. Additionally, these knockout lines are invaluable tools in the study of epigenetics, gene regulation, and cellular responses to treatments, thus bridging discoveries from bench to bedside.

Compared to alternative models, RSF1 Gene Knockout Cell Lines provide a more relevant approach to studying the functional consequences of gene loss. Traditional methods, such as siRNA knockdown, often fail to achieve complete gene ablation, whereas CRISPR-Cas9-mediated knockout presents a precise and stable genetic alteration.

For researchers and clinicians, these knockout cell lines are crucial since they enable them to explore novel therapeutic avenues for cancer treatment, ultimately supporting the development of more effective therapies. With our company’s commitment to cutting-edge genetic engineering and cell model innovation, we ensure the highest quality and reliability in our RSF1 Gene Knockout Cell Lines, reinforcing our position as a leader in biological product offerings and advancing the frontiers of scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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