Gene: RRP8
Official Full Name: ribosomal RNA processing 8provided by HGNC
Gene Summary: Enables methylated histone binding activity. Involved in several processes, including cellular response to glucose starvation; intrinsic apoptotic signaling pathway by p53 class mediator; and regulation of gene expression. Acts upstream of with a negative effect on regulation of G1 to G0 transition. Located in several cellular components, including cytosol; nuclear lumen; and rDNA heterochromatin. Part of eNoSc complex. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29349 | RRP8 Knockout cell line (HeLa) | Human | RRP8 | 1:3~1:6 | Negative | Online Inquiry |
KO29350 | RRP8 Knockout cell line (HCT 116) | Human | RRP8 | 1:2~1:4 | Negative | Online Inquiry |
KO29351 | RRP8 Knockout cell line (HEK293) | Human | RRP8 | 1:3~1:6 | Negative | Online Inquiry |
KO29352 | RRP8 Knockout cell line (A549) | Human | RRP8 | 1:3~1:4 | Negative | Online Inquiry |
RRP8 Gene Knockout Cell Lines are engineered cellular models designed to study the functional role of the RRP8 gene, which is pivotal in ribosome biogenesis and cellular proliferation. By employing CRISPR-Cas9 gene editing technology, these cell lines exhibit a precise knockout of the RRP8 gene, allowing researchers to investigate the phenotypic and metabolic consequences of RRP8 loss in a controlled environment.
The key function of RRP8 is its involvement in the processing and assembly of ribosomal RNA, crucial for the formation of ribosomes. This structure is fundamental for protein synthesis in cells. By utilizing RRP8 knockout cell lines, scientists can elucidate how disruptions in this process may lead to cellular stresses or disease states, including cancer and developmental disorders. The application of these cell lines extends beyond basic research; they provide invaluable tools for drug screening and therapeutic interventions targeting ribosome-related pathologies in clinical settings.
One of the significant advantages of RRP8 Gene Knockout Cell Lines is their precision and reliability compared to standard wild-type cell lines or less specific models. This specificity facilitates the generation of reproducible data essential for drawing accurate correlations between RRP8 dysfunction and observed cellular effects. Furthermore, these cell lines come with robust characterization, ensuring that researchers can trust the consistency of their experimental results.
For researchers and clinicians engaged in developmental biology, cancer research, or genetic studies, RRP8 Gene Knockout Cell Lines represent a crucial advancement. They offer an unparalleled opportunity to dissect the cellular mechanisms at play in ribosomal assembly and the implications of RRP8 deficiency.
Our company specializes in the development of innovative genetic models tailored for research applications, guided by a commitment to scientific rigor and quality. With extensive expertise in gene editing technologies, we provide researchers with essential tools to drive their discoveries forward.
Please note that all services are for research use only. Not intended for any clinical use.
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