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RRM2B Knockout Cell Lines

Gene: RRM2B

Official Full Name: ribonucleotide reductase regulatory TP53 inducible subunit M2Bprovided by HGNC

Gene Summary: This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06831 RRM2B Knockout cell line (HeLa) Human RRM2B 1:3~1:6 Negative Online Inquiry
KO06832 RRM2B Knockout cell line (HCT 116) Human RRM2B 1:2~1:4 Negative Online Inquiry
KO06833 RRM2B Knockout cell line (HEK293) Human RRM2B 1:3~1:6 Negative Online Inquiry
KO06834 RRM2B Knockout cell line (A549) Human RRM2B 1:3~1:4 Negative Online Inquiry

Background

RRM2B Gene Knockout Cell Lines represent a cutting-edge biological tool designed for researchers seeking to elucidate the roles of the RRM2B gene in various cellular processes and disease states. RRM2B, a critical component of the ribonucleotide reductase complex, plays an essential role in the synthesis of deoxyribonucleotides for DNA replication and repair. By employing CRISPR/Cas9 technology, our RRM2B Gene Knockout Cell Lines effectively disrupt the RRM2B gene, providing a powerful platform to study cellular responses linked to DNA damage, cellular proliferation, and apoptosis.

The key function of these knockout cell lines is to enable researchers to observe and evaluate the phenotypic changes resulting from the loss of RRM2B function. This includes alterations in cell cycle regulation, oxidative stress response, and potential implications in various diseases, such as cancer and neurodegenerative disorders. The ability to induce a specific genetic deficiency allows scientists to unravel the mechanistic pathways influenced by RRM2B and assess the gene's involvement in cellular metabolism and genome stability.

In the realm of scientific research, RRM2B Gene Knockout Cell Lines have significant implications. Their applications span across fundamental biology, translational research, and the development of therapeutic strategies. By providing a means to investigate gene function in vitro, these cell lines facilitate a greater understanding of disease mechanisms and aid in the discovery of novel treatment targets.

What distinguishes our RRM2B Gene Knockout Cell Lines from alternatives is the precision and reliability of our gene-editing technology, coupled with the extensive characterization of the lines. Each knockout is verified through genotyping and functional assays to ensure consistent and reproducible results, giving researchers confidence in their findings.

For researchers and clinicians, the value of these cell lines lies in their ability to bridge the gap between genetic studies and clinical applications. By employing these tools, professionals can uncover insights that drive future innovations in diagnostics and therapeutics. Our company is committed to advancing biological research products, backed by expertise in genetic engineering and a robust portfolio of tools tailored for impactful scientific inquiries.

Please note that all services are for research use only. Not intended for any clinical use.

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