Gene: RRAGB
Official Full Name: Ras related GTP binding Bprovided by HGNC
Gene Summary: Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09213 | RRAGB Knockout cell line (HeLa) | Human | RRAGB | 1:3~1:6 | Negative | Online Inquiry |
KO09214 | RRAGB Knockout cell line (HCT 116) | Human | RRAGB | 1:2~1:4 | Negative | Online Inquiry |
KO09215 | RRAGB Knockout cell line (HEK293) | Human | RRAGB | 1:3~1:6 | Negative | Online Inquiry |
KO09216 | RRAGB Knockout cell line (A549) | Human | RRAGB | 1:3~1:4 | Negative | Online Inquiry |
RRAGB Gene Knockout Cell Lines are precisely engineered cellular models in which the RRAGB gene, implicated in the regulation of cellular signaling pathways associated with nutrient sensing and mTOR pathway activation, has been specifically disrupted. These knockout cell lines provide invaluable tools for researchers investigating the roles of RRAGB in various biological processes, including cell growth, differentiation, and metabolism.
The primary function of these cell lines is to nullify the expression of the RRAGB gene, thus enabling the study of its physiological roles in real-time within a controlled environment. Through gene editing technologies such as CRISPR-Cas9, these knockout lines allow for the observation of changes in cellular behavior that occur in the absence of RRAGB, thereby elucidating its contributions to mTOR signaling and various stress responses. This aspect is particularly crucial in cancer research, where aberrant mTOR signaling is a hallmark.
The scientific importance of RRAGB Gene Knockout Cell Lines lies in their application across a variety of research domains, including cancer biology, metabolic disorders, and neurobiology. By utilizing these models, researchers can conduct functional assays, screen for therapeutic compounds, or explore gene interactions, advancing our understanding of complex diseases.
Compared to traditional methods such as pharmacological inhibition or overexpression studies, the use of knockout cell lines affords greater specificity and control, allowing for more reliable data interpretation. The targeted deletion of the RRAGB gene minimizes off-target effects and provides a clearer picture of gene function.
Moreover, these cell lines represent a significant advantage for clinicians and researchers seeking robust, adaptable models that reflect the nuances of human biology. The fidelity of gene knockout technology enables the translation of findings into potential therapeutic targets, fostering innovation in drug development.
Backed by our extensive expertise in cell line development and molecular biology, our RRAGB Gene Knockout Cell Lines stand out as a premier product for the scientific community. We are dedicated to supporting researchers’ quest for breakthroughs in understanding disease mechanisms and developing new therapeutic strategies.
Please note that all services are for research use only. Not intended for any clinical use.
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