Gene: RPRD1A
Official Full Name: regulation of nuclear pre-mRNA domain containing 1Aprovided by HGNC
Gene Summary: This gene encodes a cell-cycle and transcription regulatory protein. The encoded protein interacts with the cell cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may function as a negative regulator of G(1)/S phase progression. This protein also forms homo- and hetrodimers with the protein, regulation of nuclear pre-mRNA domain-containing protein 1B, to form a scaffold that interacts with the C-terminal domain of RNA polymerase II subunit B1 and regulates several aspects of transcription. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Dec 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14425 | RPRD1A Knockout cell line (HeLa) | Human | RPRD1A | 1:3~1:6 | Negative | Online Inquiry |
KO14426 | RPRD1A Knockout cell line (HCT 116) | Human | RPRD1A | 1:2~1:4 | Negative | Online Inquiry |
KO14427 | RPRD1A Knockout cell line (HEK293) | Human | RPRD1A | 1:3~1:6 | Negative | Online Inquiry |
KO14428 | RPRD1A Knockout cell line (A549) | Human | RPRD1A | 1:3~1:4 | Negative | Online Inquiry |
RPRD1A Gene Knockout Cell Lines are specialized cellular models that have undergone targeted gene editing to disable the expression of the RPRD1A gene. This product represents a significant advancement in the tools available for molecular biology and genetics research. RPRD1A is known to play a crucial role in the regulation of RNA splicing and transcriptional processes, making these knockout cell lines invaluable for researchers aiming to dissect the gene's functional contributions within diverse biological contexts.
The key mechanism by which these cell lines operate hinges on the complete loss of RPRD1A function, providing an effective platform to study the gene’s role in cellular mechanisms, such as the response to stress, gene regulation, and tumorigenesis. By introducing this knockout model into experimental workflows, researchers can investigate the downstream effects of RPRD1A disruption, elucidating its involvement in critical pathways.
Scientifically, the RPRD1A Gene Knockout Cell Lines can be utilized in both basic research and translational settings. Their applications range from exploring cancer biology and potential therapeutic targets to understanding splicing mechanisms and regulatory networks. The unique capability to analyze the phenotypic and molecular consequences of RPRD1A deficiency can accelerate the discovery of novel biological insights and therapeutic approaches.
The advantages of using RPRD1A Gene Knockout Cell Lines over traditional models lie in their precision and reproducibility. These cell lines offer researchers a consistent environment to pursue their experiments, minimizing variability often seen with other experimental methods. Additionally, the ability to generate isogenic pairs allows for direct comparison with control lines, enhancing the robustness of experimental findings.
For researchers and clinicians engaged in genetic studies or molecular pathology, the RPRD1A Gene Knockout Cell Lines represent an essential tool for advancing knowledge and discovery. The precise targeting of this gene provides a unique opportunity to delve deeper into complex biological mechanisms that underpin many diseases.
Our company specializes in developing innovative and high-quality biological products. With a commitment to supporting the scientific community, we offer superior cell lines, including the RPRD1A Gene Knockout Cell Lines, to empower researchers in their quest for groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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