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RNF7 Knockout Cell Lines

Gene: RNF7

Official Full Name: ring finger protein 7provided by HGNC

Gene Summary: The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33023 RNF7 Knockout cell line (HeLa) Human RNF7 1:3~1:6 Negative Online Inquiry
KO33024 RNF7 Knockout cell line (HCT 116) Human RNF7 1:2~1:4 Negative Online Inquiry
KO33025 RNF7 Knockout cell line (HEK293) Human RNF7 1:3~1:6 Negative Online Inquiry
KO33026 RNF7 Knockout cell line (A549) Human RNF7 1:3~1:4 Negative Online Inquiry

Background

RNF7 Gene Knockout Cell Lines are specialized cell lines engineered to specifically disrupt the expression of the RNF7 gene, a critical component in various cellular processes, including protein degradation and DNA damage response. By utilizing advanced CRISPR-Cas9 technology, these cell lines facilitate the exploration of RNF7's functional role in cellular mechanisms, thus providing a powerful tool for researchers investigating gene function and regulation.

The key function of RNF7 gene knockout is to disrupt the ubiquitin-proteasome pathway by inhibiting RNF7's E3 ubiquitin ligase activity, which is essential for modulating protein levels and maintaining cellular homeostasis. The resulting alterations in proteostasis can help elucidate pathways related to cancer progression, immune response, and cellular senescence, affording researchers the opportunity to identify novel therapeutic targets and biomarkers.

The scientific importance of RNF7 Gene Knockout Cell Lines is underscored by their applications in both fundamental research and clinical settings. They enable studies on DNA repair mechanisms and stress responses, essential in understanding tumorigenesis and the development of resistance to therapies. Moreover, these cell lines can serve as valuable models for drug discovery, elucidating how the targeting of RNF7-related pathways can potentially enhance therapeutic efficacy.

One of the primary advantages of RNF7 Gene Knockout Cell Lines lies in their specificity; they offer a precise means to study gene function without off-target effects that are often present in alternative gene editing methods. Additionally, these cell lines are validated and optimized for reproducibility and ease of use, ensuring that researchers can realize consistent results across experiments.

For those in academia, industry, and clinical research, the value of RNF7 Gene Knockout Cell Lines is evident. They empower scientists to bridge gaps in our understanding of complex biological processes and to develop innovative solutions for pressing health challenges. Trust in our dedicated team's expertise, which is backed by years of experience in biological product development and a commitment to advancing scientific research through high-quality offerings.

Please note that all services are for research use only. Not intended for any clinical use.

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