Gene: RNF217
Official Full Name: ring finger protein 217provided by HGNC
Gene Summary: This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21461 | RNF217 Knockout cell line (HeLa) | Human | RNF217 | 1:3~1:6 | Negative | Online Inquiry |
KO21462 | RNF217 Knockout cell line (HCT 116) | Human | RNF217 | 1:2~1:4 | Negative | Online Inquiry |
KO21463 | RNF217 Knockout cell line (HEK293) | Human | RNF217 | 1:3~1:6 | Negative | Online Inquiry |
KO21464 | RNF217 Knockout cell line (A549) | Human | RNF217 | 1:3~1:4 | Negative | Online Inquiry |
RNF217 Gene Knockout Cell Lines are genetically-engineered cellular models designed to specifically delete the RNF217 gene, which encodes a key protein implicated in various cellular processes, including protein ubiquitination and regulation of cell signaling pathways. This product is invaluable for studying the role of RNF217 in disease mechanisms, particularly in cancers and neurodegenerative disorders, providing insights into the gene's contribution to cellular homeostasis and pathology.
The RNF217 knockout is achieved through advanced CRISPR/Cas9 technology, which allows for precise editing of the genomic sequence. By selectively knocking out the RNF217 gene, researchers can elucidate the functional consequences of its absence on cell proliferation, apoptosis, and related pathways, facilitating a better understanding of disease models. Through this functional analysis, scientists can target therapeutic strategies that may restore normal cellular functions in disease contexts or develop novel drug candidates.
The scientific importance of RNF217 Gene Knockout Cell Lines extends to both research and clinical applications. These cell lines serve as crucial platforms for drug screening, biomarker identification, and validation studies, thereby accelerating the translation of basic research findings into clinical practice. Furthermore, the ability to develop RNF217-deficient models enhances the understanding of individual variability in disease susceptibility and drug response.
What sets our RNF217 Gene Knockout Cell Lines apart from other genetic models is the stringent quality control and validation processes they undergo. Each cell line is characterized for gene editing efficiency, expression profiling, and functional assays, ensuring that researchers obtain reliable and reproducible results. Additionally, these cell lines are readily available in various backgrounds, tailored to meet different research needs, and decrease the time required for model development.
For researchers and clinicians seeking to advance their work, the RNF217 Gene Knockout Cell Lines present a powerful tool to dissect the complexities of RNF217-related pathologies. Our company prides itself on its extensive expertise in genetic engineering and cell line development, offering a wide range of high-quality biological products that empower the scientific community in their quest for understanding and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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