Gene: RNF19A
Official Full Name: ring finger protein 19A, RBR E3 ubiquitin protein ligaseprovided by HGNC
Gene Summary: This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28649 | RNF19A Knockout cell line (HeLa) | Human | RNF19A | 1:3~1:6 | Negative | Online Inquiry |
KO28650 | RNF19A Knockout cell line (HCT 116) | Human | RNF19A | 1:2~1:4 | Negative | Online Inquiry |
KO28651 | RNF19A Knockout cell line (HEK293) | Human | RNF19A | 1:3~1:6 | Negative | Online Inquiry |
KO28652 | RNF19A Knockout cell line (A549) | Human | RNF19A | 1:3~1:4 | Negative | Online Inquiry |
RNF19A Gene Knockout Cell Lines are specifically engineered cellular models that have undergone targeted gene disruption of the RNF19A gene. This process creates a powerful research tool for elucidating the gene's function in various biological pathways and disease states. The knockout technique is achieved using CRISPR-Cas9 technology, recognized for its precision in generating mutations that can lead to complete gene inactivity.
The key function of RNF19A Gene Knockout Cell Lines lies in their ability to facilitate the study of RNF19A's role in cellular processes such as protein ubiquitination and degradation, cell cycle regulation, and stress response. By removing the activity of this gene, researchers can explore the downstream effects on signal transduction pathways and cellular outcomes, enhancing our understanding of its contributions to diseases, particularly cancer and neurodegenerative disorders.
The scientific importance of RNF19A Gene Knockout Cell Lines is substantial, as they are instrumental in both basic and applied research. In clinical settings, these cell lines can accelerate the development of therapeutic strategies, facilitate drug screening, and provide insights into biomarker identification for patient stratification. Furthermore, they serve as vital tools for the validation of RNF19A as a potential therapeutic target.
Compared to other cellular models, RNF19A Gene Knockout Cell Lines offer unique advantages, including robust specificity and reproducibility in genetic editing, leading to more reliable experimental data. Additionally, unlike traditional knockdown methods that may leave residual gene expression, our knockout process ensures complete suppression of RNF19A, resulting in clearer interpretations of functional studies.
Researchers and clinicians will find RNF19A Gene Knockout Cell Lines immensely valuable for their innovative approach to understanding gene functionality and disease mechanisms. This product embodies the intersecting paths of basic research and clinical application, marking an essential resource for advancing therapeutic development.
Our company specializes in developing high-quality biological products, ensuring that our offerings are backed by rigorous scientific validation and cutting-edge technology. We are committed to supporting the research community with top-tier tools for the exploration of genetic functions.
Please note that all services are for research use only. Not intended for any clinical use.
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