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RNF169 Knockout Cell Lines

Gene: RNF169

Official Full Name: ring finger protein 169provided by HGNC

Gene Summary: Enables K63-linked polyubiquitin modification-dependent protein binding activity; nucleosome binding activity; and ubiquitin-modified histone reader activity. Involved in double-strand break repair via homologous recombination and negative regulation of double-strand break repair. Located in cytosol; nuclear lumen; and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21170 RNF169 Knockout cell line (HeLa) Human RNF169 1:3~1:6 Negative Online Inquiry
KO21171 RNF169 Knockout cell line (HCT 116) Human RNF169 1:2~1:4 Negative Online Inquiry
KO21172 RNF169 Knockout cell line (HEK293) Human RNF169 1:3~1:6 Negative Online Inquiry
KO21173 RNF169 Knockout cell line (A549) Human RNF169 1:3~1:4 Negative Online Inquiry

Background

RNF169 Gene Knockout Cell Lines are specially engineered cellular models designed to facilitate the targeted study of the RNF169 gene's function within various biological processes. Utilizing CRISPR/Cas9 technology, these knockout cell lines exhibit precise deletions of the RNF169 gene, allowing researchers to explore its role in protein regulation, cellular signaling, and stress responses.

The key function of RNF169 is believed to be involved in modulating DNA damage repair mechanisms and regulating inflammatory responses. By creating RNF169 knockout cell lines, researchers can elucidate the gene's contributions to oncogenesis and immune signaling pathways. The lack of RNF169 in these cell models allows for a clearer understanding of the gene's functional consequences, facilitating in-depth investigations into underlying molecular mechanisms.

In research and clinical settings, RNF169 Gene Knockout Cell Lines represent an invaluable tool for gene function studies, drug discovery, and gene therapy developments. They provide a reproducible and controlled environment to investigate the effects of RNF169 absence on various cellular processes, including proliferation, apoptosis, and response to external stressors. This specificity can enhance the effectiveness of therapeutic strategies aimed at targeting aberrant gene functions.

Compared to traditional methods of gene silencing, such as RNA interference, our RNF169 knockout lines offer a permanent and precise gene alteration, allowing for sustained studies over time without off-target effects. This distinction not only enhances experimental validity but also streamlines workflows in busy research environments.

For researchers and clinicians looking to deepen their understanding of the genetic underpinnings of diseases linked to RNF169, these knockout cell lines are an advantageous addition to their toolkit. They foster innovative research and potential clinical applications, specifically in oncology and immunotherapy.

Our company specializes in providing high-quality, genetically modified cell lines supported by extensive expertise in molecular biology and genomics. We are dedicated to empowering the scientific community with tools that enhance research capabilities and promote advancements in biomedical science.

Please note that all services are for research use only. Not intended for any clinical use.

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