Gene: RNF130
Official Full Name: ring finger protein 130provided by HGNC
Gene Summary: The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growth factor withdrawal-induced apoptosis of myeloid precursor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14469 | RNF130 Knockout cell line (HeLa) | Human | RNF130 | 1:3~1:6 | Negative | Online Inquiry |
KO14470 | RNF130 Knockout cell line (HCT 116) | Human | RNF130 | 1:2~1:4 | Negative | Online Inquiry |
KO14471 | RNF130 Knockout cell line (HEK293) | Human | RNF130 | 1:3~1:6 | Negative | Online Inquiry |
KO14472 | RNF130 Knockout cell line (A549) | Human | RNF130 | 1:3~1:4 | Negative | Online Inquiry |
RNF130 Gene Knockout Cell Lines represent a cutting-edge biological tool that enables researchers to investigate the function of the RNF130 gene in various cellular processes. RNF130 is an E3 ubiquitin ligase involved in key regulatory pathways, and its knockout can shed light on its role in protein degradation, signaling pathways, and disease mechanisms. These cell lines are meticulously developed through CRISPR/Cas9 technology, ensuring precise editing of the RNF130 gene, which allows for a more straightforward analysis of loss-of-function effects on cellular phenotypes.
The primary function of these knockout cell lines is to facilitate the study of the upstream and downstream biological interactions related to RNF130. By eliminating this gene, researchers can observe changes in protein abundance, signaling cascades, and overall cellular behavior, thus obtaining invaluable insights into its relevance in cellular homeostasis, immune response, and oncogenesis. Furthermore, these models can serve as a platform for drug testing and therapeutic intervention studies, enhancing their utility in translational research.
The scientific importance of RNF130 knockout cell lines extends to multiple fields, including cancer research, immunology, and neuroscience, where they can be instrumental in elucidating the role of RNF130 in pathologies and potential treatment strategies. Compared to traditional mutant models, these knockout cell lines offer a faster and more standardized approach to gene functional studies, significantly reducing research timelines and improving experimental reproducibility.
Unique advantages of RNF130 Gene Knockout Cell Lines include their high specificity and flexibility for use in various in vitro systems, their compatibility with high-throughput screening, and the extensive characterization data provided with each line. Research professionals and clinicians benefit from such tools as they are designed to maximize experimental efficiency, yielding consistent and reliable data.
Our company has extensive experience in producing high-quality gene knockout models, ensuring that researchers have access to robust, validated systems tailored to their specific research needs. With our commitment to innovation and scientific excellence, the RNF130 Gene Knockout Cell Lines are a key addition to your molecular biology toolkit.
Please note that all services are for research use only. Not intended for any clinical use.
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