Gene: RIN2
Official Full Name: Ras and Rab interactor 2provided by HGNC
Gene Summary: The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. Mutations in this gene cause macrocephaly alopecia cutis laxa and scoliosis (MACS) syndrome, an elastic tissue disorder, as well as the related connective tissue disorder, RIN2 syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04005 | RIN2 Knockout cell line (HeLa) | Human | RIN2 | 1:3~1:6 | Negative | Online Inquiry |
KO04006 | RIN2 Knockout cell line (A549) | Human | RIN2 | 1:3~1:4 | Negative | Online Inquiry |
RIN2 Gene Knockout Cell Lines are genetically engineered cellular models designed to facilitate the study of the RIN2 gene's functional role in cellular processes and disease mechanisms. These cell lines are generated using advanced CRISPR-Cas9 technology, resulting in precise deletions of the RIN2 gene. By eliminating this gene, researchers can effectively assess its contribution to essential biological pathways, including cellular signaling, endocytosis, and intracellular trafficking.
The primary function of RIN2 is to facilitate the docking and fusion of vesicles within cells, making it a crucial component of vesicular trafficking and membrane dynamics. By utilizing RIN2 Gene Knockout Cell Lines, scientists can elucidate the biological roles of RIN2 in various contexts, such as cancer research, neurobiology, and metabolic disorders. These knockout models serve as powerful tools for investigating the gene's regulatory networks and its downstream effects, providing insights that are critical for developing therapeutic strategies targeting related pathways.
The scientific importance of these cell lines extends to both research and clinical applications. In a laboratory setting, RIN2 knockout lines allow for high-throughput screening of compounds that may modulate the functions related to the absence of RIN2, making them invaluable in drug discovery initiatives. Furthermore, understanding RIN2's role in pathophysiology can have significant implications for developing targeted interventions in clinical practice.
In comparison to traditional gene silencing methods, such as RNA interference, our RIN2 Gene Knockout Cell Lines offer a more stable and long-lasting approach to studying gene function. This innovative model enables reproducible results over time, improving the reliability of experimental findings. Additionally, the specificity of knockout constructs minimizes off-target effects, enhancing the accuracy of research outcomes.
Researchers and clinicians utilizing RIN2 Gene Knockout Cell Lines can expect a paradigm shift in their approach to exploring gene functionality, with potential breakthroughs in understanding disease mechanisms and discovering novel therapeutic strategies. Our commitment to providing high-quality, genetically validated cellular models is backed by years of experience in developing cutting-edge biological products tailored to the needs of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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