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RHBDD2 Knockout Cell Lines

Gene: RHBDD2

Official Full Name: rhomboid domain containing 2provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the rhomboid family of membrane-bound proteases and is overexpressed in some breast cancers. Members of this family are involved in intramembrane proteolysis. In mouse, the orthologous protein associates with the Golgi body. [provided by RefSeq, Sep 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14566 RHBDD2 Knockout cell line (HeLa) Human RHBDD2 1:3~1:6 Negative Online Inquiry
KO14567 RHBDD2 Knockout cell line (HCT 116) Human RHBDD2 1:2~1:4 Negative Online Inquiry
KO14568 RHBDD2 Knockout cell line (HEK293) Human RHBDD2 1:3~1:6 Negative Online Inquiry
KO14569 RHBDD2 Knockout cell line (A549) Human RHBDD2 1:3~1:4 Negative Online Inquiry

Background

RHBDD2 Gene Knockout Cell Lines are specially engineered cellular models that facilitate the study of the RHBDD2 gene, known for its role in regulating cellular processes such as protein degradation and stress response. This product encompasses a series of cultured mammalian cells where the RHBDD2 gene has been systematically disrupted. The knockout of this gene allows researchers to investigate downstream effects on various signaling pathways, providing insights into its biological significance and potential implications in disease pathology.

The knockout mechanism operates through advanced genome editing technologies, typically CRISPR/Cas9, which enable precise modifications to the genetic material. This approach results in the complete loss of functional RHBDD2 protein, permitting a controlled environment to study cellular behaviors absent this critical regulator. By assessing changes in cellular phenotypes, such as protein accumulation, cell viability, and stress response, researchers can glean important information regarding the gene's contributions to homeostasis.

The scientific importance of RHBDD2 Gene Knockout Cell Lines is profound, particularly in the domains of cancer research and neurodegenerative diseases. These cell lines serve as invaluable tools in understanding the underlying mechanisms of diseases, facilitating drug discovery, and offering a platform for gene therapy development. Furthermore, they can be instrumental in validating potential therapeutic targets and biomarkers, enhancing translational research efforts.

Compared to conventional wild-type cell lines, RHBDD2 knockout models provide a unique advantage by eliminating background interference from the gene’s normal function. This specificity allows for clearer interpretation of experimental outcomes, ultimately leading to more robust and reproducible results. Additionally, these cell lines are compatible with various downstream applications, including high-throughput screening and functional assays.

For researchers and clinicians focused on gene function, disease mechanisms, and therapeutic strategies, RHBDD2 Gene Knockout Cell Lines represent a critical addition to their experimental toolbox. The potential for uncovering novel insights into RHBDD2-related pathways could lead to breakthroughs in treatment paradigms.

As a leader in the field, our company is dedicated to providing high-quality biological products and personalized support, ensuring that you can leverage our expertise to further your research endeavors and maximize the impact of your work.

Please note that all services are for research use only. Not intended for any clinical use.

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