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RGS7 Knockout Cell Lines

Gene: RGS7

Official Full Name: regulator of G protein signaling 7provided by HGNC

Gene Summary: Enables G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and GTPase activator activity. Involved in G protein-coupled receptor signaling pathway; negative regulation of G protein-coupled receptor signaling pathway; and positive regulation of GTPase activity. Located in cytosol. Is active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35641 RGS7 Knockout cell line (HEK293) Human RGS7 1:3~1:6 Negative Online Inquiry

Background

RGS7 Gene Knockout Cell Lines represent a groundbreaking tool designed to investigate the biological roles of the RGS7 (Regulator of G-Protein Signaling 7) gene in cellular signaling pathways. By utilizing CRISPR/Cas9 gene-editing technology, these cell lines have been specifically engineered to lack the RGS7 gene, enabling researchers to study its contributions to G-protein coupled receptor (GPCR) signaling and its implications in various physiological and pathological conditions.

The primary function of RGS7 lies in its ability to accelerate the deactivation of G-proteins, thus serving as a crucial regulator of signal transduction. By examining RGS7 gene knockout cell lines, scientists can elucidate the downstream effects of disrupted signaling pathways, providing insights into various processes such as neuropsychiatric disorders, cardiovascular diseases, and metabolic syndromes. These cell lines enable the dissection of complex signaling networks with unprecedented precision, facilitating both basic and translational research.

The scientific importance of RGS7 gene knockout cell lines cannot be overstated. Their application spans from fundamental studies in cellular biology to targeted drug discovery efforts aimed at GPCR-related disorders. Researchers can leverage these unique models to validate therapeutic hypotheses, screen potential compounds, and enhance the understanding of receptor functionality, thereby accelerating the path from bench to bedside.

Unlike traditional cell lines, RGS7 gene knockout cell lines provide a clean background devoid of the confounding signals from the RGS7 protein, allowing for more specific and reproducible results. This specificity enhances the reliability of experimental outcomes, thus giving researchers a competitive edge in their investigations. Moreover, these cell lines offer versatility, being suitable for use in a variety of assays, from high-throughput screening to functional studies at the molecular level.

For researchers and clinicians seeking to advance their understanding of GPCR signaling and its implications in health and disease, RGS7 Gene Knockout Cell Lines serve as an invaluable resource. With a commitment to pioneering biological products, our company brings expertise in gene editing technology and a deep understanding of cellular interactions, ensuring that researchers have access to high-quality models that support their scientific endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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