Home / RGS20 Knockout Cell Lines

RGS20 Knockout Cell Lines

Gene: RGS20

Official Full Name: regulator of G protein signaling 20provided by HGNC

Gene Summary: The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34029 RGS20 Knockout cell line (HeLa) Human RGS20 1:3~1:6 Negative Online Inquiry
KO34030 RGS20 Knockout cell line (HCT 116) Human RGS20 1:2~1:4 Negative Online Inquiry
KO34031 RGS20 Knockout cell line (HEK293) Human RGS20 1:3~1:6 Negative Online Inquiry
KO34032 RGS20 Knockout cell line (A549) Human RGS20 1:3~1:4 Negative Online Inquiry

Background

RGS20 Gene Knockout Cell Lines are genetically engineered cell lines in which the Regulator of G-Protein Signaling 20 (RGS20) gene has been inactivated or "knocked out." RGS20 is part of the RGS family of proteins, which play a critical role in regulating G-protein signaling pathways. These pathways are pivotal for various cellular processes, including proliferation, differentiation, and response to extracellular signals. The knockout of RGS20 allows researchers to study its specific functions and interactions within signaling cascades, providing deeper insights into its role in cellular physiology and pathology.

The mechanism of action behind RGS20 gene knockout involves targeted disruption of the gene through techniques such as CRISPR-Cas9, enabling precise modifications at the genomic level. By eliminating RGS20, scientists can observe resultant effects on G-protein coupled receptor (GPCR) signaling, elucidate pathways involved in disease mechanisms, and explore potential therapeutic targets. Furthermore, RGS20 is implicated in various disorders, making these knockout cell lines particularly valuable for drug discovery and development.

In research and clinical settings, RGS20 Gene Knockout Cell Lines serve as powerful tools for investigating GPCR signaling pathways and their correlation with disease states, which can lead to innovative therapeutic strategies. Compared to traditional cell lines, these knockout models offer a more definitive approach for dissecting specific signaling mechanisms, making them essential for researchers focused on signal transduction and cellular response.

The advantages of utilizing RGS20 Gene Knockout Cell Lines include their robustness, reproducibility, and specific targeting of the RGS20 gene, minimizing off-target interactions common in other models. This specificity enhances data reliability and accelerates research timelines.

For researchers, clinicians, and pharmaceutical companies, the RGS20 Gene Knockout Cell Lines provide a unique opportunity to unravel complex biological questions and drive advancements in therapeutic development. Our company proudly leverages cutting-edge genetic engineering techniques and a rich background in cellular biology to offer high-quality products that meet the demands of modern biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.