Gene: RFX6
Official Full Name: regulatory factor X6provided by HGNC
Gene Summary: The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis.[provided by RefSeq, Sep 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27098 | RFX6 Knockout cell line (HEK293) | Human | RFX6 | 1:3~1:6 | Negative | Online Inquiry |
RFX6 Gene Knockout Cell Lines are specialized cell lines engineered to lack the functional RFX6 gene, which is crucial for various biological processes, including the development of the pancreas and the regulation of insulin secretion. These knockout models allow researchers to study the specific roles of RFX6 in metabolic pathways and understand its implications in diseases such as diabetes and pancreatic cancer.
The primary function of these cell lines is to enable the investigation of gene function by providing a platform that mimics a loss-of-function scenario. Through techniques such as CRISPR-Cas9 gene editing, the RFX6 gene is targeted and rendered inoperative, facilitating studies on how its absence influences cellular behavior, signaling pathways, and overall homeostasis. Researchers can utilize these models to explore the molecular mechanisms behind RFX6-related disorders, revealing important insights into cellular dysregulation and potential therapeutic targets.
The significance of RFX6 Gene Knockout Cell Lines extends to both academic research and clinical applications. In laboratories, they are invaluable for drug discovery, where understanding gene function can lead to innovative treatments for diseases linked to RFX6. Clinicians are also able to utilize this tool to pursue personalized medicine strategies, tailoring interventions based on genetic insights.
Compared to traditional cell lines that express RFX6, our knockout lines provide a more accurate representation of disease mechanisms. This specificity allows for higher relevance in experimental outcomes, addressing key gaps in current research. The unique selling points of these cell lines include their reliable performance, comprehensive background information, and the ability to facilitate reproducible results, which are essential for robust scientific investigation.
By choosing RFX6 Gene Knockout Cell Lines, researchers and clinicians can advance their understanding of gene function with a high degree of accuracy, ultimately driving innovative solutions in the health sciences. Our company prides itself on its commitment to excellence in biological products, supported by a robust platform of research expertise and technical support, ensuring that users derive maximum benefit from our offerings.
Please note that all services are for research use only. Not intended for any clinical use.
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