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RFX1 Knockout Cell Lines

Gene: RFX1

Official Full Name: regulatory factor X1provided by HGNC

Gene Summary: This gene encodes a member of the regulatory factor X (RFX) family of transcription factors, which are characterized by a winged-helix DNA-binding domain. The encoded transcription factor contains an N-terminal activation domain and a C-terminal repression domain, and may activate or repress target gene expression depending on cellular context. This transcription factor has been shown to regulate a wide variety of genes involved in immunity and cancer, including the MHC class II genes and genes that may be involved in cancer progression. This gene exhibits altered expression in glioblastoma and the autoimmune disease systemic lupus erythematosis (SLE). [provided by RefSeq, Jul 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35637 RFX1 Knockout cell line (HeLa) Human RFX1 1:3~1:6 Negative Online Inquiry
KO35638 RFX1 Knockout cell line (HCT 116) Human RFX1 1:2~1:4 Negative Online Inquiry
KO35639 RFX1 Knockout cell line (HEK293) Human RFX1 1:3~1:6 Negative Online Inquiry
KO35640 RFX1 Knockout cell line (A549) Human RFX1 1:3~1:4 Negative Online Inquiry

Background

RFX1 Gene Knockout Cell Lines are genetically modified cell lines in which the RFX1 gene has been selectively disrupted or knocked out. This product serves as a crucial tool for researchers studying gene function, signaling pathways, and various cellular mechanisms in both normal and pathological states. By eliminating the RFX1 gene, these cell lines allow for detailed analysis of the gene’s contributions to immune responses, development, and potential disease mechanisms, especially in cancer and autoimmune disorders.

The primary function of RFX1 is to regulate the transcription of MHC class II genes, which are essential for presenting antigens to T cells, thereby playing a vital role in adaptive immunity. The knockout of the RFX1 gene in these cell lines enables researchers to investigate the downstream effects on immune signaling and cellular behavior, providing insights into how these pathways can be manipulated for therapeutic purposes. Furthermore, these models facilitate the exploration of RFX1’s role in other cellular processes, fostering a comprehensive understanding of its multifunctional nature.

The scientific significance of RFX1 Gene Knockout Cell Lines extends beyond basic research; they hold the potential to yield findings that inform clinical strategies for treating disorders linked to immune dysregulation. Compared to traditional approaches, such as CRISPR/Cas9 gene editing in non-targeted cells, these pre-established knockout lines offer a more rapid and reliable means of obtaining results, significantly enhancing experimental efficiency.

For researchers and clinicians, the exceptional usability of RFX1 Gene Knockout Cell Lines presents an invaluable advantage, allowing them to focus their efforts on deriving meaningful insights and validating hypotheses without the delay of establishing knockout models from scratch. Furthermore, the availability of well-characterized cell lines ensures consistency and reproducibility in experiments, which is crucial for high-quality research outcomes.

As a leader in the biotechnological landscape, our company is committed to providing top-tier biological products. We leverage advanced genetic engineering techniques to develop high-quality knockout cell lines that empower scientists to delve deeper into their inquiries, driving innovation and discovery within the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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