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REXO1 Knockout Cell Lines

Gene: REXO1

Official Full Name: RNA exonuclease 1 homologprovided by HGNC

Gene Summary: Predicted to enable exonuclease activity. Predicted to be involved in rRNA 3'-end processing. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14592 REXO1 Knockout cell line (HeLa) Human REXO1 1:3~1:6 Negative Online Inquiry
KO14593 REXO1 Knockout cell line (HCT 116) Human REXO1 1:2~1:4 Negative Online Inquiry
KO14594 REXO1 Knockout cell line (HEK293) Human REXO1 1:3~1:6 Negative Online Inquiry
KO14595 REXO1 Knockout cell line (A549) Human REXO1 1:3~1:4 Negative Online Inquiry

Background

REXO1 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of the REXO1 gene, which is a critical player in cellular RNA metabolism and mitochondrial function. By employing advanced genomic editing techniques such as CRISPR-Cas9, these cell lines exhibit complete knockout of the REXO1 gene, eliminating its expression and allowing researchers to explore the downstream effects and compensatory mechanisms involved in its loss. This creates a powerful tool for dissecting the role of REXO1 in various biological processes and diseases.

The primary function of the REXO1 gene is to encode a protein that is involved in the degradation of RNA molecules, thereby influencing RNA quality control and turnover. This process is vital for maintaining cellular homeostasis and preventing the accumulation of defective RNA species that could lead to cellular dysfunction. In addition, REXO1 has been implicated in viral replication and resistance, highlighting its relevance in virology and host-pathogen interactions. The REXO1 Gene Knockout Cell Lines provide a robust platform to elucidate these pathways, enabling researchers to perform functional assays and explore potential therapeutic targets.

In the context of research and clinical applications, these cell lines can significantly accelerate the understanding of diseases linked to mitochondrial dysfunction and RNA metabolism, including neurodegenerative disorders and certain cancers. By utilizing REXO1 knockout models, researchers can investigate how the loss of REXO1 contributes to pathophysiology, allowing for the development of targeted interventions.

A standout feature of REXO1 Gene Knockout Cell Lines is their specificity and reliability compared to other gene editing models, which may exhibit off-target effects or incomplete gene disruption. These cell lines provide a consistent and reproducible system that ensures the fidelity of experimental results, thereby enhancing the validity of research findings.

For researchers and clinicians, the value of REXO1 Gene Knockout Cell Lines lies not only in their innovative design but also in the potential to unlock new insights into fundamental biological processes and therapeutic targets. Our company's dedication to cutting-edge biotechnology and rigorous quality control guarantees that researchers are equipped with the best tools to advance their scientific inquiries. With a solid foundation in genomic technologies, we are committed to empowering the research community with reliable and effective biological products that drive discovery and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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