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REL Knockout Cell Lines

Gene: REL

Official Full Name: REL proto-oncogene, NF-kB subunitprovided by HGNC

Gene Summary: This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08898 REL Knockout cell line (HeLa) Human REL 1:3~1:6 Negative Online Inquiry
KO08899 REL Knockout cell line (HCT 116) Human REL 1:2~1:4 Negative Online Inquiry
KO08900 REL Knockout cell line (HEK293) Human REL 1:3~1:6 Negative Online Inquiry
KO08901 REL Knockout cell line (A549) Human REL 1:3~1:4 Negative Online Inquiry

Background

REL Gene Knockout Cell Lines are precisely engineered cellular models designed to investigate the functional roles of the REL gene, which is integral to various biological processes, including immune response and cellular proliferation. By employing CRISPR-Cas9 technology, these cell lines enable users to create specific, targeted gene knockouts, effectively silencing the REL gene. This allows researchers to study the resultant phenotypic changes and delineate the pathways influenced by REL in both normal and pathological states.

The primary function of REL Gene Knockout Cell Lines revolves around their use as experimental platforms for elucidating the underlying mechanisms associated with REL-mediated signaling pathways. By disrupting REL expression, researchers can assess changes in cellular behavior, such as alterations in growth, apoptosis, and response to stimuli, thereby providing critical insights into the gene's role in disease mechanisms, particularly in cancer and autoimmune disorders. The ability to utilize these knockout models in both in vitro and in vivo experiments makes them exceptionally versatile for translational research.

Scientifically, these cell lines hold immense importance in drug development and therapeutic research, where understanding gene function is essential for designing effective treatments. Moreover, REL Gene Knockout Cell Lines offer a unique advantage over other experimental systems, such as wild-type models or other gene-editing approaches, by providing a more straightforward and reliable way to study gene function in a controlled environment. Their specificity and reproducibility significantly reduce experimental variability, offering confidence in the resulting data.

These products are of paramount value to researchers and clinicians seeking to uncover novel therapeutic targets or biomarker candidates, particularly in oncology and immunology. The REL Gene Knockout Cell Lines empower scientists with the tools necessary to rigorously investigate the processes that underlie complex diseases, positioning them at the forefront of cutting-edge research.

Our company specializes in providing high-quality biological products tailored for advanced research purposes, and our expertise in gene editing technologies ensures that our customers receive top-tier, rigorously validated cell lines to support their groundbreaking studies.

Please note that all services are for research use only. Not intended for any clinical use.

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