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RCC2 Knockout Cell Lines

Gene: RCC2

Official Full Name: regulator of chromosome condensation 2provided by HGNC

Gene Summary: The protein encoded by this gene is a guanine exchange factor that is active on RalA, a small GTPase. The encoded protein and RalA are both essential for proper kinetochore-microtubule function in early mitosis. This protein has been shown to be a biomarker for colorectal cancer. [provided by RefSeq, Oct 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14642 RCC2 Knockout cell line (HeLa) Human RCC2 1:3~1:6 Negative Online Inquiry
KO14643 RCC2 Knockout cell line (HCT 116) Human RCC2 1:2~1:4 Negative Online Inquiry
KO14644 RCC2 Knockout cell line (HEK293) Human RCC2 1:3~1:6 Negative Online Inquiry
KO14645 RCC2 Knockout cell line (A549) Human RCC2 1:3~1:4 Negative Online Inquiry

Background

RCC2 Gene Knockout Cell Lines are a advanced biological research tool derived from the disruption of the RCC2 gene, a key player in cellular processes such as mitotic spindle assembly, cell division, and DNA repair mechanisms. These knockout cell lines provide researchers with invaluable resources for studying the cellular consequences of RCC2 absence, facilitating a deeper understanding of cancer biology and other diseases related to cell cycle dysregulation.

The functional mechanism of RCC2 knockout cell lines involves the strategic deletion or inactivation of the RCC2 gene, leading to cellular phenotypes characterized by impaired proliferation and aberrant cytokinesis. This alteration allows for the examination of downstream signaling pathways involved in cell cycle progression and genomic stability. Researchers can utilize these cell lines in functional assays, including proliferation, migration, and invasion studies, thereby elucidating the multifaceted roles of RCC2 in oncogenic processes and potential therapeutic responses.

The scientific importance of RCC2 Gene Knockout Cell Lines extends beyond basic research; they serve as critical models for drug discovery and biomarker identification in clinical settings. The insights gained from their usage can inform targeted therapies and personalized medicine approaches, especially in tumor types where RCC2 dysfunction is implicated.

Compared to alternative products, such as RNA interference techniques or transient transfection methods, the use of RCC2 knockout cell lines provides a stable genetic modification that offers a long-term solution for understanding gene function. Researchers can rely on these models for reproducibility and consistent results across experiments.

In an era of increasing complexity in disease mechanisms, RCC2 Gene Knockout Cell Lines stand out as a powerful asset for researchers and clinicians aiming to make breakthroughs that contribute to our understanding of cellular dynamics and to the development of innovative therapeutic strategies. Our company specializes in providing high-quality, rigorously validated cell lines, ensuring that your research not only advances understanding but also achieves replicable and relevant outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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