Gene: RBFOX2
Official Full Name: RNA binding fox-1 homolog 2provided by HGNC
Gene Summary: This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00043 | RBFOX2 Knockout cell line (293T) | Human | RBFOX2 | 1:3~1:6 | Negative | Online Inquiry |
KO29168 | RBFOX2 Knockout cell line (HeLa) | Human | RBFOX2 | 1:3~1:6 | Negative | Online Inquiry |
KO29169 | RBFOX2 Knockout cell line (HCT 116) | Human | RBFOX2 | 1:2~1:4 | Negative | Online Inquiry |
KO29170 | RBFOX2 Knockout cell line (HEK293) | Human | RBFOX2 | 1:3~1:6 | Negative | Online Inquiry |
KO29171 | RBFOX2 Knockout cell line (A549) | Human | RBFOX2 | 1:3~1:4 | Negative | Online Inquiry |
RBFOX2 Gene Knockout Cell Lines are specially engineered cellular models designed to facilitate the study of the RBFOX2 gene, which is integral in the regulation of alternative splicing events during mRNA processing. By utilizing CRISPR/Cas9 technology, these cell lines have been selectively modified to disrupt the RBFOX2 gene, enabling researchers to investigate the gene's functional role and its impact on cell physiology and pathology, specifically in diseases associated with aberrant splicing mechanisms.
The primary function of the RBFOX2 gene involves contributing to the intricate process of alternative splicing, which allows for the generation of multiple mRNA isoforms from a single gene, thus diversifying protein expression and function. These knockout cell lines serve as a valuable tool for elucidating the consequences of RBFOX2 disruption on gene expression profiles and splicing patterns. This knowledge is critical in understanding various diseases, including cancer and neurodegenerative disorders, where dysregulation of splicing can lead to pathological states.
Scientifically, RBFOX2 Gene Knockout Cell Lines hold significant importance in both basic research and clinical applications. They offer a reliable model for dissecting the molecular mechanisms underlying splicing-related diseases and provide a platform for testing potential therapeutic interventions aimed at restoring normal splicing processes. Furthermore, these cell lines can be employed in drug discovery, enabling researchers to evaluate how pharmacological agents can influence splicing outcomes.
One of the key advantages of our RBFOX2 Gene Knockout Cell Lines is their precision and reliability, offering a robust system that surpasses traditional models prone to variability. Our products undergo rigorous validation to ensure consistent performance, making them ideal for experimental reproducibility. Additionally, as dedicated providers of high-quality biological research tools, we back our cell lines with extensive technical support, ensuring researchers can achieve their objectives efficiently.
By choosing our RBFOX2 Gene Knockout Cell Lines, researchers and clinicians gain access to a powerful resource that not only enhances their understanding of splicing regulation but also contributes to the advancement of targeted therapeutic strategies, ultimately leading to improved patient outcomes in diseases influenced by alternative splicing. Our commitment to excellence in biological product offerings makes us a trusted partner in the pursuit of scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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