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RASGRP2 Knockout Cell Lines

Gene: RASGRP2

Official Full Name: RAS guanyl releasing protein 2provided by HGNC

Gene Summary: The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10509 RASGRP2 Knockout cell line (HCT 116) Human RASGRP2 1:2~1:4 Negative Online Inquiry
KO10510 RASGRP2 Knockout cell line (HEK293) Human RASGRP2 1:3~1:6 Negative Online Inquiry
KO10511 RASGRP2 Knockout cell line (A549) Human RASGRP2 1:3~1:4 Negative Online Inquiry

Background

RASGRP2 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to study the effects of the RASGRP2 gene, which plays a critical role in signal transduction pathways and cellular communication. By introducing targeted gene deletions, these knockout cell lines provide researchers with a powerful tool to explore the biological functions and molecular mechanisms mediated by RASGRP2, which is known to influence cellular processes such as proliferation, differentiation, and immune responses.

The key mechanism of these cell lines lies in the disruption of RASGRP2 expression, which allows for the investigation of downstream signaling cascades, particularly those involving RAS, a crucial protein in many growth factor pathways. By observing changes in cell behavior and signaling dynamics, researchers gain insights into the implications of RASGRP2 in various physiological and pathological contexts, including its potential contributions to cancer, immune disorders, and cardiovascular diseases.

The scientific importance of RASGRP2 Gene Knockout Cell Lines extends to both basic research and therapeutic development. In research settings, they facilitate the elucidation of complex signal transduction networks. Clinically, understanding RASGRP2's role can lead to novel targets for drug development and innovative treatment strategies for diseases associated with aberrant signaling.

What sets RASGRP2 Gene Knockout Cell Lines apart from alternative products is their precise genetic editing and ease of use, ensuring high reproducibility and reliability in experimental setups. Additionally, these cell lines are compatible with a variety of assays, from functional studies to high-throughput screening, making them versatile and valuable in a range of research applications.

The value of RASGRP2 Gene Knockout Cell Lines to researchers and clinicians alike cannot be overstated: they empower professionals to advance their understanding of crucial biological processes and contribute to the development of groundbreaking therapies. With a commitment to innovation and quality, our company provides genetically modified research tools backed by an expert team dedicated to supporting scientific discovery and advancement.

Please note that all services are for research use only. Not intended for any clinical use.

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