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RASEF Knockout Cell Lines

Gene: RASEF

Official Full Name: RAS and EF-hand domain containingprovided by HGNC

Gene Summary: This gene is a member of the Rab family of GTPases that are involved in regulation of membrane traffic. The encoded protein contains an N-terminal EF-hand domain, a coiled-coil motif and a C-terminal Rab domain. A potential role as tumor suppressor has been indicated for this gene. [provided by RefSeq, Nov 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20251 RASEF Knockout cell line (HeLa) Human RASEF 1:3~1:6 Negative Online Inquiry
KO20252 RASEF Knockout cell line (HEK293) Human RASEF 1:3~1:6 Negative Online Inquiry
KO20253 RASEF Knockout cell line (A549) Human RASEF 1:3~1:4 Negative Online Inquiry

Background

RASEF Gene Knockout Cell Lines are advanced research tools designed to facilitate the study of gene function and protein interactions by allowing precise manipulation of the RASEF gene. RASEF (RAS and EF-hand domain-containing protein) plays a crucial role in various cellular processes, including signal transduction pathways that are intimately involved in cell proliferation, differentiation, and apoptosis. The RASEF Gene Knockout Cell Lines are engineered using CRISPR-Cas9 technology to provide a high specificity and efficiency in gene disruption, leading to the creation of cells devoid of RASEF expression.

These knockout cell lines operate through targeted editing at the genomic level. By introducing double-strand breaks in the targeted gene and utilizing the cell's natural repair mechanisms, researchers can effectively introduce insertions or deletions in the RASEF gene, leading to frameshift mutations that result in the loss of functional protein production. This mechanism not only provides a definitive approach to understanding the biological roles of RASEF but also allows for high-throughput screening and validation of potential therapeutic targets in cancer and other diseases.

The scientific importance of RASEF Gene Knockout Cell Lines is pronounced; they serve as valuable models in various areas of biological research, including cancer biology, developmental biology, and drug discovery. Their application extends to fundamental studies of cell signaling, where researchers can elucidate the consequences of RASEF loss on cellular behavior and investigate the gene's potential role in oncogenesis.

What sets our RASEF Gene Knockout Cell Lines apart from alternatives is their rigorous validation, ensuring that they provide reproducible and reliable data for scientific inquiries. Additionally, they are commercially available with extensive support documentation and technical assistance, making them accessible and practical for both advanced research laboratories and clinical settings.

Investing in RASEF Gene Knockout Cell Lines translates into significant advantages for researchers and clinicians seeking to deepen their understanding of cell biology and develop innovative therapeutic strategies. Our commitment to excellence in biological product development is underscored by our team of experts, who leverage cutting-edge technologies to deliver high-quality products tailored to advancing scientific knowledge and improving health outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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