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RASA2 Knockout Cell Lines

Gene: RASA2

Official Full Name: RAS p21 protein activator 2provided by HGNC

Gene Summary: The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10517 RASA2 Knockout cell line (HeLa) Human RASA2 1:3~1:6 Negative Online Inquiry
KO10518 RASA2 Knockout cell line (HCT 116) Human RASA2 1:2~1:4 Negative Online Inquiry
KO10519 RASA2 Knockout cell line (HEK293) Human RASA2 1:3~1:6 Negative Online Inquiry
KO10520 RASA2 Knockout cell line (A549) Human RASA2 1:3~1:4 Negative Online Inquiry

Background

RASA2 Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to study the roles and mechanisms of the RASA2 gene, which is implicated in various biological processes, including cell signaling, proliferation, and tumor suppression. By selectively knocking out this gene, these cell lines provide a powerful tool for researchers to assess the functional consequences of RASA2 absence on cellular behavior and related molecular pathways.

The primary function of RASA2 knockout cell lines is to enable researchers to investigate the impact of RASA2 loss on key signaling pathways such as the RAS-MAPK and PI3K-AKT pathways. The knockout is achieved through advanced gene editing techniques like CRISPR-Cas9, which ensures precise and efficient modification of the target gene. The resulting cell lines serve as invaluable models for studying diseases associated with RASA2 dysregulation, particularly in cancer research where the loss of tumor suppressor functions can illuminate mechanisms of tumorigenesis and therapeutic resistance.

In terms of scientific importance, these cell lines are crucial for translational research, providing insights that could lead to the identification of new therapeutic targets or biomarkers for patient stratification in clinical settings. Their applications span from basic biological research to drug discovery, where understanding the exact role of RASA2 can influence the development of targeted interventions.

Compared to alternative platforms such as transient transfection or siRNA knockdowns, RASA2 Gene Knockout Cell Lines offer the advantage of stable gene disruption, enabling long-term studies without the variability that comes with transient methods. This stability is essential for generating reproducible results in experiments and ensures that downstream assays can be performed with confidence.

Researchers and clinicians looking to elucidate the complexities of RASA2 in cellular contexts will find these cell lines invaluable, as they provide a robust framework to understand signaling alterations and disease mechanisms. By integrating these models into their research, users are equipped with the means to accelerate discovery in their fields.

Our company specializes in developing advanced biological products, and our RASA2 Gene Knockout Cell Lines exemplify our commitment to providing high-quality, innovative tools for the scientific community. With extensive expertise in genetic engineering and cellular biology, we strive to support researchers in their quest for knowledge and therapeutic advancement.

Please note that all services are for research use only. Not intended for any clinical use.

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