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RANBP17 Knockout Cell Lines

Gene: RANBP17

Official Full Name: RAN binding protein 17provided by HGNC

Gene Summary: The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO14713 RANBP17 Knockout cell line (HeLa) Human RANBP17 1:3~1:6 Negative Online Inquiry
KO14714 RANBP17 Knockout cell line (HCT 116) Human RANBP17 1:2~1:4 Negative Online Inquiry
KO14715 RANBP17 Knockout cell line (HEK293) Human RANBP17 1:3~1:6 Negative Online Inquiry
KO14716 RANBP17 Knockout cell line (A549) Human RANBP17 1:3~1:4 Negative Online Inquiry

Background

RANBP17 Gene Knockout Cell Lines are advanced cellular models engineered to lack the expression of the RANBP17 gene, facilitating comprehensive investigations into its functional roles in various biological processes. RANBP17, a member of the Ran-binding protein family, is implicated in regulating cellular transport mechanisms, including nucleocytoplasmic transport and mitotic spindle assembly. The knockout of this gene provides researchers with valuable tools to dissect the underlying pathways and interactomes related to RANBP17 activity, enhancing the understanding of its contribution to cellular physiology and pathology.

These cell lines operate on the principle of CRISPR-Cas9 gene editing technology, enabling precise removal of the RANBP17 sequence, which leads to observable phenotypic alterations. Researchers can utilize these models to explore diverse applications such as cancer biology studies, immunological research, and neurobiology, where the role of RANBP17 in cellular proliferation, differentiation, and apoptosis may hold potential insights into therapeutic targets.

The scientific importance of the RANBP17 Gene Knockout Cell Lines cannot be overstated, especially in translational research settings where understanding gene-specific functions can guide drug development and therapeutic interventions. Compared to traditional cell lines, these knockout models offer a more accurate representation of gene function, increasing the reliability of experimental outcomes.

Moreover, one of their standout advantages is the availability of multiple knockout variants, enabling comparative studies across different cellular contexts, which are often challenging to accomplish with other cell lines. This versatility, coupled with high specificity and reproducibility, makes RANBP17 Gene Knockout Cell Lines an invaluable asset to researchers and clinicians seeking to unravel the complexities of gene interactions.

By leveraging our expertise in genetic engineering and cell line development, our company ensures that these cell lines are rigorously characterized and validated, providing reliable tools that enhance your research and clinical workflows. Investing in RANBP17 Gene Knockout Cell Lines equips you with the means to push the frontiers of biological research and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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