Gene: RALBP1
Official Full Name: ralA binding protein 1provided by HGNC
Gene Summary: RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08894 | RALBP1 Knockout cell line (HeLa) | Human | RALBP1 | 1:3~1:6 | Negative | Online Inquiry |
KO08895 | RALBP1 Knockout cell line (HCT 116) | Human | RALBP1 | 1:2~1:4 | Negative | Online Inquiry |
KO08896 | RALBP1 Knockout cell line (HEK293) | Human | RALBP1 | 1:3~1:6 | Negative | Online Inquiry |
KO08897 | RALBP1 Knockout cell line (A549) | Human | RALBP1 | 1:3~1:4 | Negative | Online Inquiry |
RALBP1 Gene Knockout Cell Lines are genetically modified cell lines in which the RALBP1 gene (Ras-related protein Ral-B-binding protein 1) has been disrupted, enabling researchers to study the gene's functions and associated biological processes. These knockout models permit the investigation of the role of RALBP1 in cellular functions, such as endocytosis, signal transduction, and oncogenesis, by providing a controlled environment where the effects of gene loss can be directly observed.
The primary mechanism behind RALBP1 knockout involves the use of CRISPR/Cas9 technology or other gene-editing techniques to create precise mutations that inactivate the target gene. This disruption results in the loss of RALBP1 protein production, allowing for the analysis of cellular outcomes such as changes in protein interaction networks, intracellular signaling cascades, and alterations in cellular phenotypes. Researchers can ascertain how the absence of this protein affects cellular behavior, contributing valuable insights into its physiological and pathophysiological roles.
The scientific importance of RALBP1 Gene Knockout Cell Lines is underscored by their wide-ranging applications in basic research and drug discovery. They can be used to identify potential therapeutic targets in cancer and neurodegenerative diseases, where RALBP1 is suspected to play a pivotal role. Furthermore, these cell lines can facilitate high-throughput screening of compounds to uncover novel drug candidates that modulate RALBP1-related pathways.
Compared to alternative gene silencing methods such as shRNA or siRNA, RALBP1 Gene Knockout Cell Lines offer permanent and stable gene disruption, which allows for long-term studies of gene function without the transient effects often seen with RNA interference. This stability is crucial for experimental reproducibility and for understanding complex cellular responses over time.
For researchers and clinicians, the value of RALBP1 Gene Knockout Cell Lines lies in their ability to provide a robust platform for exploring gene functions and testing therapeutic interventions, ultimately guiding the translation of basic findings into clinical applications. By employing these versatile tools, scientists can enhance their understanding of RALBP1's contributions to health and disease.
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Please note that all services are for research use only. Not intended for any clinical use.
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