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RAD51B Knockout Cell Lines

Gene: RAD51B

Official Full Name: RAD51 paralog Bprovided by HGNC

Gene Summary: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35712 RAD51B Knockout cell line (HeLa) Human RAD51B 1:3~1:6 Negative Online Inquiry
KO35713 RAD51B Knockout cell line (HCT 116) Human RAD51B 1:2~1:4 Negative Online Inquiry
KO35714 RAD51B Knockout cell line (HEK293) Human RAD51B 1:3~1:6 Negative Online Inquiry
KO35715 RAD51B Knockout cell line (A549) Human RAD51B 1:3~1:4 Negative Online Inquiry

Background

RAD51B Gene Knockout Cell Lines are specifically engineered cellular models that lack the RAD51B gene, which is crucial for the homologous recombination repair pathway in DNA. This gene plays a vital role in maintaining genomic stability by facilitating the repair of DNA double-strand breaks, and its inhibition allows researchers to investigate the gene’s function and the resultant phenotypic consequences in a controlled environment.

The key function of the RAD51B gene knockout is to provide insight into the mechanistic processes of DNA repair and its implications in cancer biology. These cell lines operate by exploiting the natural DNA repair deficiency observed when RAD51B is absent, enabling researchers to study how cells cope with genomic stress and their susceptibility to various chemotherapeutic agents. This understanding is critical as it aids in elucidating potential biomarkers for cancer diagnostics and treatment efficacy.

From a scientific perspective, RAD51B Gene Knockout Cell Lines serve as an invaluable tool in both basic research and clinical applications. These cell models can be utilized to screen for novel drug compounds, explore therapeutic resistance in cancer treatments, and analyze genetic interactions with other DNA repair genes. As such, they are indispensable for developing targeted therapies and understanding the complex interplay of genetic factors in oncogenesis.

What sets RAD51B Gene Knockout Cell Lines apart from traditional cell lines is their specificity and precision in gene modification, which allows for a more accurate recreation of disease models. The targeted genetic alteration provides a level of control and reproducibility that is often lacking in other experimental systems. Furthermore, these cell lines can be easily integrated into existing research protocols, enhancing experimental robustness.

Its unique combination of applications, scientific relevance, and precision makes RAD51B Gene Knockout Cell Lines a critical asset for researchers and clinicians striving to advance their work in genomic medicine and cancer research. With a commitment to excellence, our company specializes in providing high-quality biological products tailored for cutting-edge research, enabling scientists to push the boundaries of knowledge and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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