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PYCARD Knockout Cell Lines

Gene: PYCARD

Official Full Name: PYD and CARD domain containingprovided by HGNC

Gene Summary: This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06592 PYCARD Knockout cell line (HeLa) Human PYCARD 1:3~1:6 Negative Online Inquiry
KO06593 PYCARD Knockout cell line (HCT 116) Human PYCARD 1:2~1:4 Negative Online Inquiry
KO06594 PYCARD Knockout cell line (A549) Human PYCARD 1:3~1:4 Negative Online Inquiry

Background

PYCARD Gene Knockout Cell Lines are genetically engineered cell lines designed to facilitate the study of the PYHIN domain-containing protein 1 (PYCARD), which plays a critical role in the innate immune response. These knockout cell lines are created through targeted gene editing techniques, such as CRISPR-Cas9, which enable precise disruption of the PYCARD gene, thereby providing researchers with a powerful tool to investigate its functions and regulatory mechanisms in cellular contexts.

The primary function of PYCARD is its involvement in the assembly of inflammasomes, multiprotein complexes that activate inflammatory responses in reaction to various stimuli, including microbial infections and cellular damage. By utilizing the PYCARD knockout cell lines, researchers can elucidate the pathways and interactions influenced by PYCARD, offering insights into how dysregulation may contribute to disease processes such as autoimmune disorders and cancer.

The scientific importance of these cell lines extends to both basic research and clinical applications. They enable the investigation of therapeutic targets within the inflammasome activation pathway and facilitate drug screening efforts aimed at modulating immune responses. Furthermore, the knockout lines provide a robust model system for understanding the immunological implications of PYCARD in health and disease.

What sets PYCARD Gene Knockout Cell Lines apart from alternative models is their high specificity and reproducibility, which allow for consistent experimental outcomes. Additionally, they are optimized to offer enhanced growth characteristics and viability, making them an invaluable resource for researchers seeking reliable data.

For scientists, clinicians, and pharmaceutical researchers dedicated to advancing immunology and inflammation-related studies, PYCARD Gene Knockout Cell Lines offer an essential means to drive discovery and innovation. Our commitment to quality and precision in genetic engineering underscores our expertise in providing robust biological tools. By choosing our product, you gain access to cutting-edge technology and unparalleled support, empowering your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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