Gene: PTPRK
Official Full Name: protein tyrosine phosphatase receptor type Kprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35788 | PTPRK Knockout cell line (HeLa) | Human | PTPRK | 1:3~1:6 | Negative | Online Inquiry |
KO35789 | PTPRK Knockout cell line (HCT 116) | Human | PTPRK | 1:2~1:4 | Negative | Online Inquiry |
KO35790 | PTPRK Knockout cell line (HEK293) | Human | PTPRK | 1:3~1:6 | Negative | Online Inquiry |
KO35791 | PTPRK Knockout cell line (A549) | Human | PTPRK | 1:3~1:4 | Negative | Online Inquiry |
PTPRK Gene Knockout Cell Lines are advanced cellular models engineered to specifically disrupt the function of the Protein Tyrosine Phosphatase Receptor Type K (PTPRK) gene. This gene is implicated in various biological processes including cell adhesion, signaling pathways, and cancer progression. By utilizing gene editing technologies such as CRISPR-Cas9, these knockout cell lines allow researchers to study the phenotypic and molecular consequences of PTPRK loss, providing invaluable insights into its role in health and disease.
Functionally, PTPRK gene knockout leads to alterations in phosphatase activity, affecting downstream signaling cascades critical for cellular functions. This model is particularly significant in research focused on oncogenesis and metastasis, as PTPRK is known to play a part in tumor suppression. The loss of its normal function promotes unregulated cell growth, making it a compelling target for therapeutic interventions.
The scientific importance of PTPRK Gene Knockout Cell Lines is underscored by their application in drug discovery and targeted therapy development, especially in cancer research. They serve as essential tools for elucidating the PTPRK-mediated pathways, allowing for the identification of potential biomarkers and therapeutic targets.
Compared to traditional wild-type cell line models, these knockout lines provide superior specificity and insight into the biological effects of PTPRK deletion. Researchers benefit from more accurate data that can lead to more effective therapeutic strategies.
For clinicians and researchers alike, PTPRK Gene Knockout Cell Lines represent a powerful resource for understanding disease mechanisms and developing novel interventions. Backed by our company’s extensive expertise in genetic engineering and cellular biology, we are committed to providing cutting-edge biological products that empower scientific discovery and advancement in therapeutic applications.
Please note that all services are for research use only. Not intended for any clinical use.
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