Gene: PTPRG
Official Full Name: protein tyrosine phosphatase receptor type Gprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35801 | PTPRG Knockout cell line (HCT 116) | Human | PTPRG | 1:2~1:4 | Negative | Online Inquiry |
KO35802 | PTPRG Knockout cell line (HEK293) | Human | PTPRG | 1:3~1:6 | Negative | Online Inquiry |
KO35803 | PTPRG Knockout cell line (A549) | Human | PTPRG | 1:3~1:4 | Negative | Online Inquiry |
PTPRG Gene Knockout Cell Lines are a powerful tool designed to facilitate the study of the protein tyrosine phosphatase receptor type G (PTPRG) gene. This innovative biological product involves the creation of stable cell lines in which the PTPRG gene has been specifically knocked out, thereby providing researchers with a unique model system to investigate the gene's functional role in cellular processes. By disabling the PTPRG gene, the cell lines allow for the observation of downstream signaling pathways and cellular behaviors that are influenced by this gene, offering valuable insights into its contributions to various physiological and pathological states.
The mechanisms underpinning the function of the PTPRG gene encompass several critical roles in cell signaling, including regulation of proliferation, differentiation, and apoptosis. By utilizing the knockout cell lines, scientists can delve into the phenotypic and functional changes induced by the absence of PTPRG, which may include altered cell behavior in the context of cancer, neurobiology, and cardiovascular diseases. The use of these specialized cell lines can enhance the understanding of disease mechanisms and the development of targeted therapeutic interventions.
The scientific importance of PTPRG Gene Knockout Cell Lines extends into both basic and applied research, making them indispensable in drug discovery and development. Compared to traditional knockdown methods, such as RNA interference, permanent knockout models provide more stable and long-lasting changes, resulting in clearer interpretations of the gene's effects on cellular function. Moreover, these cell lines can be readily adopted in various laboratory settings, ensuring reproducibility of results.
For researchers and clinicians, the availability of precise knockout models like PTPRG cell lines accelerates the path from hypothesis to application, facilitating breakthroughs in understanding disease etiology and exploring novel therapeutic avenues. Our commitment to advancing scientific discovery is reflected in the rigorous development and validation of this product, ensuring that users have access to high-quality research tools that empower their work. As experts in biological products, we prioritize innovation and reliability, providing solutions that meet the evolving needs of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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