Gene: PTPRD
Official Full Name: protein tyrosine phosphatase receptor type Dprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35804 | PTPRD Knockout cell line (HEK293) | Human | PTPRD | 1:3~1:6 | Negative | Online Inquiry |
PTPRD Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to lack the expression of the protein tyrosine phosphatase receptor type D (PTPRD). This product serves as a pivotal tool for researchers aiming to investigate the role of PTPRD in various biological processes, including cell signaling, proliferation, and differentiation. By utilizing these knockout cell lines, scientists can elucidate the pathways regulated by PTPRD and its implications in different disease models, particularly in cancer and neurodevelopmental disorders.
The key function of PTPRD Gene Knockout Cell Lines lies in their ability to enable functional studies through the absence of PTPRD signaling. This allows for comprehensive investigations into compensatory mechanisms that may arise, facilitating the understanding of tumorigenesis and potential therapeutic avenues. The precise gene-editing techniques used to create these knockout lines, such as CRISPR-Cas9, ensure high efficiency and specificity, leading to robust and reproducible results.
Scientifically, the importance of these cell lines is underscored by their application in both basic research and translational studies. Researchers can leverage these models to confirm hypotheses regarding PTPRD's role in disease states, thereby contributing invaluable insights into cancer biology and neurobiology. Furthermore, the ability to assess drug responses and cellular behavior in the absence of PTPRD can have profound implications for the development of targeted therapies.
Compared to alternative models, such as wild-type cell lines or overexpressing systems, PTPRD Gene Knockout Cell Lines offer a distinct advantage by providing a clearer understanding of loss-of-function scenarios. This specificity allows for deeper probing into the gene's biological functions without confounding effects from residual protein activity.
The versatility and utility of PTPRD Gene Knockout Cell Lines make them an essential asset for researchers, clinicians, and the broader scientific community. They are designed to facilitate significant discoveries and innovation, ultimately enhancing our understanding of complex biological systems and addressing unmet clinical needs.
Our company, with its expertise in genetic engineering and cellular biology, is committed to providing high-quality biological products. We take pride in the rigor of our production processes, ensuring our customers receive the most reliable tools to propel their research forward.
Please note that all services are for research use only. Not intended for any clinical use.
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