Gene: PTPN21
Official Full Name: protein tyrosine phosphatase non-receptor type 21provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31214 | PTPN21 Knockout cell line (HeLa) | Human | PTPN21 | 1:3~1:6 | Negative | Online Inquiry |
KO31215 | PTPN21 Knockout cell line (HCT 116) | Human | PTPN21 | 1:2~1:4 | Negative | Online Inquiry |
KO31216 | PTPN21 Knockout cell line (HEK293) | Human | PTPN21 | 1:3~1:6 | Negative | Online Inquiry |
KO31217 | PTPN21 Knockout cell line (A549) | Human | PTPN21 | 1:3~1:4 | Negative | Online Inquiry |
PTPN21 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to exhibit a targeted inactivation of the PTPN21 gene, which encodes a member of the protein tyrosine phosphatase family. This gene plays a crucial role in various cellular processes, including signal transduction, cell growth, and differentiation. By employing advanced CRISPR-Cas9 technology for precise genome editing, these knockout cell lines serve as invaluable tools for researchers investigating the biological functions and biochemical pathways influenced by PTPN21.
The primary function of the PTPN21 gene is to act as a regulatory protein that dephosphorylates specific target proteins, thereby modulating signaling pathways critical for cell communication and metabolic processes. By studying these knockout lines, researchers can discern the effect of the absence of PTPN21 on cellular behavior, providing insights into its role in diseases such as cancer, autoimmune disorders, and metabolic syndromes. In addition to basic research applications, these cell lines facilitate the development of therapies that target PTPN21-related pathways, highlighting their significance in translational medicine.
One of the key advantages of PTPN21 Gene Knockout Cell Lines is their unparalleled specificity and consistency, enabling reproducibility in experiments that might yield variable results with other genetic manipulation methods. Unlike conventional knockdown approaches that may only reduce gene expression or produce off-target effects, the complete knockout provides definitive insights into gene function without ambiguity. Furthermore, these cell lines can be readily integrated into various platforms, including drug screening and gene therapy investigations.
For researchers and clinicians focused on understanding the intricate role of protein tyrosine phosphatases in human health, our PTPN21 Gene Knockout Cell Lines represent an essential addition to their experimental toolkit. This product streamlines the investigative process, allowing for efficient hypothesis testing and robust data generation in a time-sensitive research environment. Backed by our company’s expertise in genetic engineering and commitment to high-quality biological products, we ensure that our cell lines meet the rigorous standards required for cutting-edge research.
Please note that all services are for research use only. Not intended for any clinical use.
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