Gene: PTOV1
Official Full Name: PTOV1 extended AT-hook containing adaptor proteinprovided by HGNC
Gene Summary: This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21929 | PTOV1 Knockout cell line (HeLa) | Human | PTOV1 | 1:3~1:6 | Negative | Online Inquiry |
KO21930 | PTOV1 Knockout cell line (HCT 116) | Human | PTOV1 | 1:2~1:4 | Negative | Online Inquiry |
KO21931 | PTOV1 Knockout cell line (HEK293) | Human | PTOV1 | 1:3~1:6 | Negative | Online Inquiry |
KO21932 | PTOV1 Knockout cell line (A549) | Human | PTOV1 | 1:3~1:4 | Negative | Online Inquiry |
PTOV1 Gene Knockout Cell Lines are precision-engineered cellular models derived from human or murine cell lines, specifically designed for the targeted disruption of the PTOV1 gene (Prostate Tumor Overexpressed 1). These genetically modified cell lines allow researchers to investigate the functional role of PTOV1 in various biological processes, particularly in cancer biology, where it is implicated in tumor growth and metastasis. By employing CRISPR-Cas9 gene editing technology, these knockout cell lines provide an effective platform for examining the gene's contributions to prostate cancer progression and response to therapies.
The primary function of PTOV1 Gene Knockout Cell Lines is to elucidate the role of the PTOV1 protein in cellular mechanisms, including its involvement in cell proliferation, apoptosis regulation, and signal transduction pathways. By observing phenotypic changes and molecular interactions associated with the loss of PTOV1, researchers can gain insights into cancer biology and the development of targeted therapeutics. These cell lines are crucial for screening compounds that can reverse or mitigate the oncogenic effects attributed to PTOV1.
Scientifically, these cell lines are invaluable tools in preclinical research and drug development. They facilitate the identification of potential biomarkers for therapy response and help in understanding the mechanisms underlying tumor resistance. Compared to conventional models, PTOV1 Gene Knockout Cell Lines offer more precise experimental conditions due to their defined genetic background, enhancing reproducibility and experimental reliability.
Moreover, their specificity for the PTOV1 gene provides researchers with unique advantages over other available models, which may not accurately replicate the gene's role in cancer. This specificity allows for focused studies on PTOV1-related pathways, underscoring the relevance of these cell lines in the quest for innovative prostate cancer therapies.
By investing in PTOV1 Gene Knockout Cell Lines, researchers and clinicians gain access to cutting-edge tools that enable profound discoveries in cancer research, ultimately leading to more effective treatment strategies. Our company specializes in providing high-quality, validated biological products that empower scientific innovation and translational research, ensuring that every product we offer contributes meaningfully to advancing health outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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