Gene: PTBP2
Official Full Name: polypyrimidine tract binding protein 2provided by HGNC
Gene Summary: The protein encoded by this gene binds to intronic polypyrimidine clusters in pre-mRNA molecules and is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein (PTB) but most of its isoforms are expressed primarily in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20214 | PTBP2 Knockout cell line (HeLa) | Human | PTBP2 | 1:3~1:6 | Negative | Online Inquiry |
KO20215 | PTBP2 Knockout cell line (HCT 116) | Human | PTBP2 | 1:2~1:4 | Negative | Online Inquiry |
KO20216 | PTBP2 Knockout cell line (HEK293) | Human | PTBP2 | 1:3~1:6 | Negative | Online Inquiry |
KO20217 | PTBP2 Knockout cell line (A549) | Human | PTBP2 | 1:3~1:4 | Negative | Online Inquiry |
PTBP2 Gene Knockout Cell Lines represent a cutting-edge tool in molecular biology, designed to facilitate the study of the polypyrimidine tract-binding protein 2 (PTBP2), a critical regulator of RNA splicing and cellular differentiation. These genetically engineered cell lines are created through advanced CRISPR-Cas9 technology, which ensures precise and efficient disruption of the PTBP2 gene, leading to the complete knockout of its function. By eliminating PTBP2 expression, researchers can investigate the gene's role in neuronal development, cell cycle regulation, and its implications in various diseases, including neurological disorders and cancers.
The key function of the PTBP2 Gene Knockout Cell Lines lies in their ability to serve as a reliable model for analyzing the downstream effects of PTBP2 loss on RNA processing and cellular behavior. Experiments using these knockout lines allow for elucidation of alternative splicing patterns, changes in gene expression, and the impact on cellular pathways. This is particularly valuable in understanding how aberrations in splicing factors contribute to pathologies, providing insights that may lead to novel therapeutic strategies.
The significance of PTBP2 Gene Knockout Cell Lines extends into several research and clinical applications. They are pivotal for drug discovery, gene therapy studies, and understanding the molecular mechanisms underlying diseases. These cell lines enable researchers to mimic specific aspects of human pathology, thereby enhancing the translational potential of their findings.
What sets PTBP2 Gene Knockout Cell Lines apart from alternative models is their specificity and robustness, allowing for reproducible results. Unlike traditional knockout models, which may involve longer timelines and less precision, these cell lines provide rapid validation tools in a controlled laboratory environment, streamlining experiments and saving time for researchers.
The value of PTBP2 Gene Knockout Cell Lines to researchers and clinicians cannot be overstated. By providing a clear framework to explore the ramifications of PTBP2 loss, these cell lines empower scientists to make significant advances in their research while potentially uncovering new avenues for treatment options.
Our company is committed to advancing life sciences by providing high-quality, scientifically validated products that facilitate groundbreaking research. With our expertise in genetic engineering and a dedicated focus on innovative solutions, we support the scientific community in achieving their research goals effectively and efficiently.
Please note that all services are for research use only. Not intended for any clinical use.
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