Gene: PTBP1
Official Full Name: polypyrimidine tract binding protein 1provided by HGNC
Gene Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO06971 | PTBP1 Knockout cell line (HeLa) | Human | PTBP1 | 1:3~1:6 | Negative | Online Inquiry |
KO06972 | PTBP1 Knockout cell line (HCT 116) | Human | PTBP1 | 1:2~1:4 | Negative | Online Inquiry |
KO06973 | PTBP1 Knockout cell line (HEK293) | Human | PTBP1 | 1:3~1:6 | Negative | Online Inquiry |
PTBP1 Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to disrupt the expression of the Polypyrimidine Tract Binding Protein 1 (PTBP1) gene. This protein is integral to numerous cellular processes, including mRNA splicing, stability, and transport, making these knockout lines invaluable for studying gene regulation and cellular behavior in various biological contexts. By removing the PTBP1 gene, researchers can delve into the downstream effects on gene expression, alternative splicing, and protein synthesis, allowing for a deeper understanding of cellular mechanisms and disease states associated with PTBP1 dysregulation.
The core functionality of the PTBP1 Gene Knockout Cell Lines lies in their capacity to model conditions mimicking certain cancers and neurodegenerative diseases where PTBP1 is implicated. The knockout is achieved through advanced CRISPR-Cas9 technology, ensuring high precision in gene editing and reproducibility across experiments. This targeted gene modification allows scientists to elucidate the role of PTBP1 in various pathways, such as cancer progression and neuronal function.
In scientific research and clinical applications, the availability of PTBP1 Gene Knockout Cell Lines fosters innovation in drug discovery, biomarker identification, and therapeutic targeting. The ability to observe phenotypic changes and gene expression profiles in response to treatments enhances the understanding of PTBP1 as a potential drug target.
What sets our PTBP1 Gene Knockout Cell Lines apart from alternative products is their rigorous validation and characterization processes, which ensure consistency, reliability, and high viability rates. We prioritize the needs of researchers by providing comprehensive data on cell behavior, growth rates, and gene expression profiles, thus facilitating the design of robust experiments.
As a leader in the field of biological cell line development, our company is committed to advancing research in molecular biology and genetics. Our expertise enables us to provide high-quality products that empower scientists and clinicians to push the boundaries of discovery and therapeutics.
Please note that all services are for research use only. Not intended for any clinical use.
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