Gene: PRRG1
Official Full Name: proline rich and Gla domain 1provided by HGNC
Gene Summary: This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35884 | PRRG1 Knockout cell line (HeLa) | Human | PRRG1 | 1:3~1:6 | Negative | Online Inquiry |
KO35885 | PRRG1 Knockout cell line (HCT 116) | Human | PRRG1 | 1:2~1:4 | Negative | Online Inquiry |
KO35886 | PRRG1 Knockout cell line (HEK293) | Human | PRRG1 | 1:3~1:6 | Negative | Online Inquiry |
KO35887 | PRRG1 Knockout cell line (A549) | Human | PRRG1 | 1:3~1:4 | Negative | Online Inquiry |
PRRG1 Gene Knockout Cell Lines are specialized cellular models engineered to selectively disable the expression of the PRRG1 gene, which has been implicated in various biological processes, including cell proliferation and differentiation. These knockout cell lines serve as powerful tools for researchers to investigate the gene’s role in physiological and pathological contexts, such as cancer and developmental biology. By employing sophisticated gene-editing techniques, such as CRISPR-Cas9, these cell lines provide a reliable platform to study the consequences of PRRG1 loss, elucidating its function in cellular signaling pathways and gene regulation.
The key functions of PRRG1 are linked to its involvement in the modulation of protein interactions that influence cellular behavior. By knocking out this gene, researchers can observe changes in cellular characteristics, such as growth rates, apoptosis, and migration patterns. This capability to visualize and measure the direct impact of PRRG1 deficiency enhances our understanding of its biological significance and potential therapeutic implications.
In clinical and research settings, PRRG1 Gene Knockout Cell Lines provide valuable insights into disease mechanisms, notably in cancer research where PRRG1 may affect tumor progression and response to therapy. These models are indispensable for drug discovery and validation, as they allow for the testing of potential therapeutic agents on genetically defined populations of cells.
Compared to traditional cell lines, our PRRG1 Gene Knockout Cell Lines offer unique advantages, including high specificity and reproducibility in experimental outcomes. Moreover, the conditional knockout options enable researchers to dissect time-dependent effects of gene loss, which is often challenging with more static models.
These knockout cell lines are essential for any research laboratory seeking to expand their understanding of gene function and disease pathology. They not only streamline experimental workflows but also facilitate reproducible and impactful findings in scientific studies.
At [Your Company Name], we pride ourselves on our expertise in developing innovative biological products tailored to the needs of researchers and clinicians. Our commitment to quality and precision ensures that our PRRG1 Gene Knockout Cell Lines are equipped to propel your research forward, unlocking new avenues of scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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